Despite technological advances and improved care delivery, antibiotic resistance and healthcare associated infections continue to plague our health system. The applicant, Dr. Aaron Milstone, is a Pediatric Infectious Diseases Physician and Epidemiologist who had focused his career on the prevention of antibiotic resistance and healthcare-associated infections. This K24 application builds on his career goals of translating laboratory and epidemiologic observations into patient- and population-level interventions and will prepare him and his trainees to identify, develop, and test new strategies to prevent infections and antibiotic resistance. The specific research aims are to: 1) identify risk factors for and develop a predictive model of carbapenem- resistant organism colonization and transmission in hospitalized patients, 2) identify bacterial communities, bacterial genes, and patient clinical characteristics associated with resistance to S. aureus nasal colonization in hospitalized neonates at risk for S. aureus acquisition from parents with known S. aureus colonization, and 3) determine whether bacterial culture stewardship reduces antibiotic use and resistance. The proposed projects will build on existing funded projects and collaborations in microbiome, genomics, and implementation science, expand the Dr. Milstone's knowledge in these areas, and make him a more effective PI and patient oriented research mentor.

Public Health Relevance

Antibiotic resistance and healthcare-associated infections are major threats to human health and are a top public health priority. This proposal will support mentoring of the next generation of investigators who will advance the science of infection prevention and protect vulnerable populations from the impact of emerging antibiotic resistance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI141580-03
Application #
10054099
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Huntley, Clayton C
Project Start
2018-11-23
Project End
2023-10-31
Budget Start
2020-11-01
Budget End
2021-10-31
Support Year
3
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205