This application is a Mid-Career Investigator Award (K24) in Patient- Oriented Research (POR) for Rosalind Ramsey-Goldman, MD, DrPH, an Associate Professor of Medicine in the Division of Arthritis and connective Tissue Diseases at Northwestern University. The PI is highly committed to POR, and this is demonstrated by her established track record for funding and publications in the area of systemic lupus erythematosis (SLE), which is a chronic, inflammatory, autoimmune disease that primarily affects women during their childbearing years. As morbidity form the disease has diminished during the last 15 years, the natural history of the disease has changed. The PI established two cohorts of patients with lupus, and these resources have focused on the long-term consequences of disease and treatment in these patients. Dr. Ramsey- Goldman has successfully obtained grant support and published her findings in pregnancy outcomes, risk of cancer, incidence of disease, and bone complications. The PI has mentoring experience with trainees including college undergraduates, predoctoral and postdoctoral PhD graduate students, medical students, and junior faculty. She is directing the mentoring program for her professional organization, the American College of Rheumatology, as Chair of the Subcommittee on Career Development and Women's Health. The research goals of this award are 1) to continue ongoing lupus research activities (osteoporosis, genetics, and cancer), 2) to pursue new research opportunities (cardiovascular disease), 3) to participate as a preceptor for a trainees' thesis project for the Masters of Public Health Program, and 4) to mentor medial students, residents, fellows, and junior faculty in their area of clinical research. Clinical research is well supported at Northwestern University, and Dr. Ramsey-Goldman has the complete support from the institution to accomplish her research goals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR002138-04
Application #
6632712
Study Section
Special Emphasis Panel (ZAR1-JRL-A (O1))
Program Officer
Serrate-Sztein, Susana
Project Start
2000-04-01
Project End
2005-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
4
Fiscal Year
2003
Total Cost
$116,319
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Hanly, John G; Li, Qiuju; Su, Li et al. (2018) Cerebrovascular Events in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. Arthritis Care Res (Hoboken) 70:1478-1487
Patel, Zubin; Lu, Xiaoming; Miller, Daniel et al. (2018) A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet :
Demirci, F Yesim; Wang, Xingbin; Morris, David L et al. (2017) Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus. J Med Genet 54:381-389
Jorge, April; Lertratanakul, Apinya; Lee, Jungwha et al. (2017) Depression and Progression of Subclinical Cardiovascular Disease in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) 69:5-11
Deng, Yun; Zhao, Jian; Sakurai, Daisuke et al. (2016) Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Ann Rheum Dis 75:2007-2013
Demirci, F Yesim; Wang, Xingbin; Kelly, Jennifer A et al. (2016) Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry. Arthritis Rheumatol 68:174-83
Zhao, Jian; Giles, Brendan M; Taylor, Rhonda L et al. (2016) Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis 75:242-52
Kottyan, Leah C; Zoller, Erin E; Bene, Jessica et al. (2015) The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet 24:582-96
Arroyo-Ávila, Mariangelí; Santiago-Casas, Yesenia; McGwin Jr, Gerald et al. (2015) Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol 34:1217-23
Zhao, Jian; Wu, Hui; Langefeld, Carl D et al. (2015) Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clin Immunol 161:157-62

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