The etiology of fibromyalgia (FM) and other chronic musculoskeletal pain syndromes remains unclear. Treatment options are limited and often ineffective. Our group considers FM to be one of a spectrum of disorders characterized by dysregulated hypothalamic-pituitary-adrenal (HPA) axis function spanning both somatic and psychiatric syndromes. The HPA axis is a principal component of the coordinate stree-response system that is activated in response to both physical and psychological stimuli. There are interactions between the HPA axis and other systems contributing to linkage between the central nervous system and peripheral structures. Evidence of functional interaction between stress response systems and descending pain modulatory pathways exists. These findings suggest a role for the central nervous system in chronic musculoskeletal pain syndromes such as FM. Our research program is a multidisciplinary effort focused on basal and stimulated HPA axis function of patients with FM that is directed by the applicant. Our program has strong institutional support from units within the institution, including the general clinical research, psychology and the Institute for Social Research, psychiatry, neurology, and internal medicine. We have developed a database of patients with FM from which patients to participate in our research efforts are recruited. There is an ongoing effort to recruit appropriate patients to participate in our programs. There is a tremendous need for clinical research in the area of musculoskeletal pain. The applicant's efforts in this area have stimulated a programmatic effort at this institution that did not previously exist. Funding from the applicants research efforts have been secured, and trainees have been recruited to participate in the research program. This award will allow for continuing high quality patient-oriented research in central and peripheral neuroendocrine function in FM and other syndromes of chronic musculoskeletal pain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR002139-02
Application #
6374344
Study Section
Special Emphasis Panel (ZAR1-JRL-A (O1))
Program Officer
Ader, Deborah N
Project Start
2000-07-01
Project End
2005-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
2
Fiscal Year
2001
Total Cost
$94,930
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Chervin, Ronald D; Teodorescu, Mihaela; Kushwaha, Ramesh et al. (2009) Objective measures of disordered sleep in fibromyalgia. J Rheumatol 36:2009-16
Glass, Jennifer M; Park, Denise C; Minear, Meredith et al. (2005) Memory beliefs and function in fibromyalgia patients. J Psychosom Res 58:263-9
Crofford, Leslie J (2002) The hypothalamic-pituitary-adrenal axis in the pathogenesis of rheumatic diseases. Endocrinol Metab Clin North Am 31:1-13