Systemic lupus erythematosus (SLE) is the prototypic systemic inflammatory autoimmune disease that affects predominantly young premenopausal women. African-American women are afflicted 3 to 4 times more frequently than Caucasian women. A major focus of the candidate's research has been in the study of 1) long-term consequences of SLE including, premature cardiovascular disease, osteoporosis and malignancy, and 2) interventions to improve quality of life. The major thrust of this application will be to further develop a strong research program examining the role of inflammation and autoimmunity on cardiovascular disease in SLE. SLE is unique in that young premenopausal women are at substantially increased risk of myocardial infarction and stroke. Several potential mechanisms exist for ischemia, such as overt vasculitis, vasospasm, microvascular disease, or thrombosis with or without atherosclerosis. We do not know the burden of atherosclerosis in SLE, the most predictive risk factors, or whether there are important racial influences. In addition to traditional factors, inflammatory, immunologic, and treatment-related factors specific to SLE are likely involved. With the support of the Mid-Career Investigator Award, the candidate will work with a multidisciplinary team of established investigators and trainees in the areas of vascular imaging, cardiovascular epidemiology, biostatistics and risk-factor measurements including, inflammatory markers and autoantibodies. This collaborative effort will provide important information regarding prevalence and extent of subclinical vascular disease and associated risk factors in SLE. More far reaching is that SLE may be an ideal experiment of nature in which to further examine the role of inflammation and immune mechanisms in atherogenesis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR002213-02
Application #
6511749
Study Section
Special Emphasis Panel (ZAR1-JRL-C (O1))
Program Officer
Gretz, Elizabeth
Project Start
2001-07-06
Project End
2006-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
2
Fiscal Year
2002
Total Cost
$109,082
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kao, Amy H; McBurney, Christine A; Sattar, Abdus et al. (2014) Relation of platelet C4d with all-cause mortality and ischemic stroke in patients with systemic lupus erythematosus. Transl Stroke Res 5:510-8
Chung, Sharon A; Brown, Elizabeth E; Williams, Adrienne H et al. (2014) Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. J Am Soc Nephrol 25:2859-70
Greco, Carol M; Nakajima, Claire; Manzi, Susan (2013) Updated review of complementary and alternative medicine treatments for systemic lupus erythematosus. Curr Rheumatol Rep 15:378
Kao, Amy H; Lertratanakul, Apinya; Elliott, Jennifer R et al. (2013) Relation of carotid intima-media thickness and plaque with incident cardiovascular events in women with systemic lupus erythematosus. Am J Cardiol 112:1025-32
Greco, Carol M; Li, Tracy; Sattar, Abdus et al. (2012) Association between depression and vascular disease in systemic lupus erythematosus. J Rheumatol 39:262-8
Chung, Sharon A; Taylor, Kimberly E; Graham, Robert R et al. (2011) Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet 7:e1001323
Dasgupta, Sudeshna; Demirci, F Yesim; Dressen, Amy S et al. (2011) Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus. BMC Med Genet 12:7
Taylor, Kimberly E; Chung, Sharon A; Graham, Robert R et al. (2011) Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet 7:e1001311
Hanly, J G; Urowitz, M B; Jackson, D et al. (2011) SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus. Ann Rheum Dis 70:961-7
Demirci, F Yesim K; Dressen, Amy S; Kammerer, Candace M et al. (2011) Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus. J Rheumatol 38:652-7

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