Nancy E. Lane, is a clinical rheumatologist and an active clinical investigator in musculoskeletal diseases with a special emphasis on osteoarthritis and osteoporosis. She is currently an NIH funded investigator conducting research on the epidemiology and genetics of prevalent and progression of hip and knee osteoarthritis. The purpose of this K24 award renewal is to continue to mentor and teach clinical research in musculoskeletal diseases at U.C. Davis School of Medicine and the University of California at San Francisco (UCSF) to junior clinical investigators by 1) Continuing the twice a month interdisciplinary clinical research seminars in musculoskeletal diseases with research presentations by junior investigators;2) Teaching a seminar to junior investigators and medical students at UCDMC on Developing a Clinical Research Protocol;4) Mentoring junior investigators in clinical and translational research with my currently funded NIH grants on the epidemiology and genetics of hip OA and Knee OA in elderly men and women;5) To be mentored senior investigators in genetic epidemiology and statistics so as to become an expert in both the epidemiology and genetics of OA..
The specific aims of the three NIH grants that Dr. Lane will use to mentor junior investigators and to gain a more thorough understanding of genetic epidemiology include 1. """"""""The epidemiology and genetics of hip OA in elderly men"""""""" are to determine the prevalence of radiographic hip OA in a cohort of 5000 elderly men, determine risk factors and genetic variants associated with prevalent hip OA. 2. """"""""The natural history of hip OA in elderly women"""""""" are to identify cases of new or worsening radiographic osteoarthritis of the hip and then to determine risk factors for hip OA. 3.""""""""Multiple Outcomes in Osteoarthritis study (MOST)"""""""" are to longitudinally evaluate the effects of three groups of factors: biomechanical factors (including physical activity-related factors), bone/structural factors and nutritional factors on the occurrence and progression of symptomatic knee OA and radiographic knee OA in a population-based sample of 3000 men and women aged 50 to 79. In total, this award will enhance the achievements of the initial K-Award by building on and solidifying the strong base of research and mentoring in musculoskeletal diseases developed within the first K-Award while taking advantage of, and melding with, the strong interest in genetics and translational research that defines the current environment of the UC Davis School of Medicine

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Chen, Faye H
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University of California Davis
Internal Medicine/Medicine
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United States
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Wise, Barton L; Niu, Jingbo; Zhang, Yuqing et al. (2018) Bone shape mediates the relationship between sex and incident knee osteoarthritis. BMC Musculoskelet Disord 19:331
Lane, Nancy E; Mohan, Geetha; Yao, Wei et al. (2018) Prevalence of glucocorticoid induced osteonecrosis in the mouse is not affected by treatments that maintain bone vascularity. Bone Rep 9:181-187
Stern, Amber Rath; Yao, Xiaomei; Wang, Yong et al. (2018) Effect of osteoporosis treatment agents on the cortical bone osteocyte microenvironment in adult estrogen-deficient, osteopenic rats. Bone Rep 8:115-124
Gourlay, Margaret L; Ritter, Victor S; Fine, Jason P et al. (2017) Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study. Arch Osteoporos 12:91
Magnitsky, Sergey; Zhang, Jinjin; Idiyatullin, Djaudat et al. (2017) Positive contrast from cells labeled with iron oxide nanoparticles: Quantitation of imaging data. Magn Reson Med 78:1900-1910
Faber, B G; Baird, D; Gregson, C L et al. (2017) DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort. Osteoarthritis Cartilage 25:2031-2038
Katzman, Wendy B; Parimi, Neeta; Mansoori, Ziba et al. (2017) Cross-Sectional and Longitudinal Associations of Diffuse Idiopathic Skeletal Hyperostosis and Thoracic Kyphosis in Older Men and Women. Arthritis Care Res (Hoboken) 69:1245-1252
Mohan, Geetha; Lay, Evan Yu-An; Berka, Haley et al. (2017) A Novel Hybrid Compound LLP2A-Ale Both Prevented and Rescued the Osteoporotic Phenotype in a Mouse Model of Glucocorticoid-Induced Osteoporosis. Calcif Tissue Int 100:67-79
Wise, B L; Niu, J; Guermazi, A et al. (2017) Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease - data from the Osteoarthritis Initiat Osteoarthritis Cartilage 25:85-93
An, H; Marron, J S; Schwartz, T A et al. (2016) Novel statistical methodology reveals that hip shape is associated with incident radiographic hip osteoarthritis among African American women. Osteoarthritis Cartilage 24:640-6

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