MENTORING AND RESEARCH IN PATIENT-ORIENTED INTEGRATIVE MEDICINE The renewal Midcareer K24 Award is for Dr. Chenchen Wang to continue her mentoring of the next generation of physician-scientists and to contribute to patient-oriented Integrative Medicine research. Dr. Wang is Professor at Tufts University School of Medicine and Director of the Center for Complementary and Integrative Medicine and holds a strong record of research, publication, and mentoring. Her long-term goal is to advance the science of Integrative Medicine to promote health and healing. Her immediate goals are to obtain protected time to expand and strengthen her innovative, multi-method, and multidisciplinary translational research and mentoring programs for chronic disabling conditions. In the First Four Years of the K24, the PI has completed four major NIH-funded clinical trials studying comparative effectiveness of mind-body interventions for chronic musculoskeletal pain, developing integrative treatment approaches in military and veterans populations, and provided groundbreaking evidence on neurobiological and physiological responses to mind-body interventions. In this period, the PI published 61 articles, 8 as first author and 53 as senior author. The PI and her mentored team also received a new R01-like grant from the U.S. Department of Veterans Affairs to investigate the efficacy of a mind-body intervention for veterans suffering with Gulf War Illness. During the initial K24 period, she has been primary or co-primary mentor for 23 trainees with doctoral degrees. Her trainees authored 41 first-authored peer-reviewed publications and had 64 co-authorships. Ten of her trainees have their own NIH or other career grants. Dr. Wang?s multidisciplinary mentoring program, as well as her expertise on mind-body interventions, has been fully integrated into the research and teaching infrastructure of the Tufts Clinical and Translational Science Institute. With access to these outstanding resources and a long-recognized diverse training environment, her selected mentees will continue to obtain training in the rigorous scientific methodology, integrity, ethics, and grant applications necessary to stimulate high-quality, translational, patient-oriented research. The goal of this proposed K24 renewal is to build upon previous and current findings of the PI?s NIH-funded studies to: 1) expand and evaluate translational Integrative Medicine research for chronic disabling conditions in order to inform and benefit medical practice; 2) advance fundamental neuroscience and human biology research to understand the mechanisms of mind-body approaches, with the goal to improve chronic pain management; 3) identify critical unmet needs of novel effective therapies for managing symptoms; and 4) further strengthen the comprehensive interdisciplinary mentoring plan and extend opportunities to new scientists to guide future generations of Integrative Medicine researchers. This K24 renewal will therefore promote multidisciplinary patient-oriented research for the next generation of investigators in order to substantially advance the science on complementary and integrative medicine and contribute to the health, healthcare, and well-being for all.

Public Health Relevance

) The complementary and integrative medicine approach offers promising therapies to affect the progression of disease while simultaneously diminishing pain and morbidity. This K24 Midcareer Investigator Award renewal will expand and strengthen Dr. Wang?s multidisciplinary mentoring and research program for the next generation of integrative medicine researchers. The program will substantially advance the science of Integrative Medicine to contribute to the direction of future medicine.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Special Emphasis Panel (ZAT1)
Program Officer
Mudd, Lanay Marie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tufts University
United States
Zip Code
Bannuru, Raveendhara R; Osani, Mikala C; Al-Eid, Fatimah et al. (2018) Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis. Semin Arthritis Rheum 48:416-429
Lee, A C; Harvey, W F; Han, X et al. (2018) Pain and functional trajectories in symptomatic knee osteoarthritis over up to 12 weeks of exercise exposure. Osteoarthritis Cartilage 26:501-512
Lee, Augustine C; Harvey, William F; Price, Lori Lyn et al. (2018) Dose-Response Effects of Tai Chi and Physical Therapy Exercise Interventions in Symptomatic Knee Osteoarthritis. PM R 10:712-723
Kong, Jian; Wolcott, Emily; Wang, Zengjian et al. (2018) Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention. Brain Imaging Behav :
Lee, Augustine C; Bloch, Rina M; Harvey, William F et al. (2018) Could Activity Modifications Indicate Physical Decline Among Adults With Symptomatic Knee Osteoarthritis? Am J Phys Med Rehabil 97:96-103
Seto, Andrew; Han, Xingyi; Price, Lori Lyn et al. (2018) The role of personality in patients with fibromyalgia. Clin Rheumatol :
Wang, Chenchen; Schmid, Christopher H; Fielding, Roger A et al. (2018) Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial. BMJ 360:k851
Lee, Augustine C; Driban, Jeffrey B; Price, Lori Lyn et al. (2017) Responsiveness and Minimally Important Differences for 4 Patient-Reported Outcomes Measurement Information System Short Forms: Physical Function, Pain Interference, Depression, and Anxiety in Knee Osteoarthritis. J Pain 18:1096-1110
Lee, A C; Harvey, W F; Price, L L et al. (2017) Mindfulness is associated with psychological health and moderates pain in knee osteoarthritis. Osteoarthritis Cartilage 25:824-831
Marszalek, Jolanta; Price, Lori Lyn; Harvey, William F et al. (2017) Outcome Expectations and Osteoarthritis: Association of Perceived Benefits of Exercise With Self-Efficacy and Depression. Arthritis Care Res (Hoboken) 69:491-498

Showing the most recent 10 out of 26 publications