The long-term objectives of this K24 proposal are to enhance my research productivity and develop new skills in patient-oriented research as well as provide mentorship to increase the number of well-trained clinical investigators capable of providing future mentorship in palliative and end-of-life care. Candidate: As a medical oncologist in thoracic oncology, I am acutely aware of the suffering experienced by patients with advanced cancers and their families. The focus of my research is on developing and testing interventions to improve the quality of life and comprehensive cancer care for patients and their families. I have a strong record of patient-oriented research in palliative and end-of-life care, independent peer-reviewed funding, high quality original publications and effective mentoring. My experience as both a primary research mentor and as Fellowship Director of the Hematology/Oncology training program at my institution over the last seven years has prepared me to expand my mentoring in patient-oriented research. I will substantially alter my current roles and responsibilities to dedicate 50% effort to augment my research program and activities, with a minimum of 25% effort dedicated exclusively to mentoring. I will step down as Fellowship Director (30% effort) to invest time in learning additional research skills and serving new roles i research leadership and mentoring. Environment: The environment at Massachusetts General Hospital (MGH) Cancer Center is ideally suited to support my goals of enhancing my research and mentoring productivity in order to expand the pool of well- trained clinical investigators. The Cancer Center has welcomed and supported the formation of collaborations with palliative care, psycho-oncology, and behavioral medicine to accommodate my novel research program in palliative and end-of-life care. Notably, the Cancer Center has endorsed a new Cancer Outcomes Research Program, under my direction, with the goal of providing mentorship and support to fellows and junior faculty in health services and outcomes research. Additionally, I have access to incredibly talented trainees from Harvard University and Medical School, Harvard-affiliated residency programs, the Dana-Farber/MGH Hematology/Oncology fellowship program, the MGH Behavioral Medicine Program and junior faculty at MGH. Research: My research focuses on evaluating models of integrated palliative and oncology care as well as enhancing clinician-patient communication about end-of-life care. The new projects proposed in this K24 award build on my research in integrated palliative care to study key elements of palliative care communication, communication differences between palliative and oncology care, and the relationship between shared decision-making and patients'end-of life care outcomes. These analyses will allow us to define the roles for palliative care and oncology clinicians to provide optimal care for patients with advanced cancers and to develop data-driven guidelines for best practices and educational programs. The new research in this application also seeks to expand the scope of palliative and supportive care research to patient populations with somewhat better prognosis than those typically included in palliative care studies. These projects offer significant opportunities for mentees to learn how to develop, implement, and test palliative and supportive care interventions. Immediate and Long-Term Career Goal: My immediate career goal is to enhance my productivity and mentoring efforts in patient-oriented research in palliative and end-of-life care. This K24 proposal coincides with a plan to restructure substantially my current responsibilities as I step down as Fellowship Director and take on new roles as Director of the newly-established Cancer Outcomes Research Program and as mentor for the MGH Cancer Center K12 Program. My long-term career goal is to be at the forefront of palliative and end-of-life care research that establishes evidence-based standards for providing comprehensive cancer care, while mentoring the next generation of clinical investigators. This field of intervention development to improve the experience of patients and their families and enhance patient-clinician communication is in its infancy. To enable this program of research to flourish, I strive to conduct the highest quality patient-oriented studies and mentor junior investigators, with the aim of improving the quality of life and care for individuals impacted by cancer. Key Elements of the Research Career Development Plan: My career development plan includes a training strategy to ensure that the K24 award augments my patient-oriented research and mentoring goals. Specifically, I will collaborate with two of the nation's leading communication experts, learn new skills in qualitative methods and medical decision-making, and complete on-site training with experts in palliative care intervention development and education. The training plan will substantially add to my current research skills by enabling me to study the communication techniques used palliative care clinicians and how their approach differs from communication by oncology clinicians. I will also train in medical decision-making to investigate the relationship between shared decision-making and patients'decisions about care at the end of life.

Public Health Relevance

All patients with advanced cancer experience some degree of suffering as they confront the physical and psychological sequelae of their diagnosis and treatment. The overarching long-term objective of this proposal is to improve the quality of life and delivery of comprehensive cancer care for patients with advanced cancer by investigating innovative supportive care interventions, including early involvement of palliative care. This goal will be accomplished by expanding the candidate's patient-oriented research program and mentoring highly- qualified trainees from a variety of disciplines to increase the pool of clinical investigators studying palliative and supportive care interventions.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
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Budget End
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Fiscal Year
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Massachusetts General Hospital
United States
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El-Jawahri, Areej; Fishman, Sarah R; Vanderklish, Julie et al. (2018) Pilot study of a multimodal intervention to enhance sexual function in survivors of hematopoietic stem cell transplantation. Cancer 124:2438-2446
Lage, Daniel E; Nipp, Ryan D; D'Arpino, Sara M et al. (2018) Predictors of Posthospital Transitions of Care in Patients With Advanced Cancer. J Clin Oncol 36:76-82
Nipp, Ryan D; El-Jawahri, Areej; D'Arpino, Sara M et al. (2018) Symptoms of posttraumatic stress disorder among hospitalized patients with cancer. Cancer 124:3445-3453
Nipp, Ryan D; Fuchs, Georg; El-Jawahri, Areej et al. (2018) Sarcopenia Is Associated with Quality of Life and Depression in Patients with Advanced Cancer. Oncologist 23:97-104
Nipp, Ryan D; Temel, Jennifer S (2018) Harnessing the Power of Patient-Reported Outcomes in Oncology. Clin Cancer Res 24:1777-1779
Greer, Joseph A; Jacobs, Jamie M; El-Jawahri, Areej et al. (2018) Role of Patient Coping Strategies in Understanding the Effects of Early Palliative Care on Quality of Life and Mood. J Clin Oncol 36:53-60
El-Jawahri, Areej; Traeger, Lara; Shin, Jennifer A et al. (2017) Qualitative Study of Patients' and Caregivers' Perceptions and Information Preferences About Hospice. J Palliat Med 20:759-766
El-Jawahri, Areej; Traeger, Lara; Greer, Joseph A et al. (2017) Effect of Inpatient Palliative Care During Hematopoietic Stem-Cell Transplant on Psychological Distress 6 Months After Transplant: Results of a Randomized Clinical Trial. J Clin Oncol 35:3714-3721
Nipp, Ryan D; Greer, Joseph A; El-Jawahri, Areej et al. (2017) Coping and Prognostic Awareness in Patients With Advanced Cancer. J Clin Oncol 35:2551-2557
Shaffer, Kelly M; Jacobs, Jamie M; Nipp, Ryan D et al. (2017) Mental and physical health correlates among family caregivers of patients with newly-diagnosed incurable cancer: a hierarchical linear regression analysis. Support Care Cancer 25:965-971

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