This proposal for a K24 Mid-Career Investigator Award is being submitted to the National Institute on Drug Abuse (NIDA) for the support of Dr. Richard D. Moore to continue and enhance a program of patient-oriented research and training focused on HIV-infected patients with a history of drug abuse. Supported by a prior 5-year R01 from AHCPR and now an RO1 from NIDA, Dr. Moore has developed a longitudinal database of HIV-infected patients receiving care in an urban HIV center. This database captures comprehensive information on the treatment and subsequent clinical progression of HIV infection. The methodology is well-established and the database currently has over 10,000 person-years of follow-up time. The patients are predominantly of minority race and poor, with a high proportion of women. Illicit drug use is the most common risk factor for HIV transmission (>50 percent of all new enrollees) with active illicit drug use a continuing problem in the majority of these patients. The current focus of Dr. Moore's research efforts is on the HIV-infected illicit drug user. The specific research aims of this proposal are: 1 ) assess utilization patterns of new antiretroviral and other drug therapy, 2) assess the long-term effectiveness of combination antiretroviral therapy in slowing progression of HIV disease and prolonging survival, and 3) assess the costs of HIV care. Preliminary data suggest that illicit drug users may be less likely to receive or maintain use of HIV therapy and have a higher rate of failure with poorer outcomes than non-drug users. Determining the reasons for this and designing interventions to improve outcomes is critical future goal in order to save lives and reduce transmission of resistant HIV. Dr. Moore's research and training program have been highly productive with over 125 manuscripts and abstracts produced and over 25 postdoctoral fellows, graduate students and other young investigators mentored. This K24 Award will be an important contribution to future research productivity at the interface of HIV infection and substance abuse, and in the mentoring and training of future clinical investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA000432-05
Application #
6797916
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Lambert, Elizabeth
Project Start
2000-09-25
Project End
2005-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
5
Fiscal Year
2004
Total Cost
$124,749
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Dubrow, Robert; Qin, Li; Lin, Haiqun et al. (2017) Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. J Acquir Immune Defic Syndr 75:382-390
Muzaale, A D; Althoff, K N; Sperati, C J et al. (2017) Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors. Am J Transplant 17:1823-1832
Buchacz, Kate; Lau, Bryan; Jing, Yuezhou et al. (2016) Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010. J Infect Dis 214:862-72
Pettit, April C; Mendes, Adell; Jenkins, Cathy et al. (2016) Timing of Antiretroviral Treatment, Immunovirologic Status, and TB Risk: Implications for Testing and Treatment. J Acquir Immune Defic Syndr 72:572-8

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