? This is a new application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Linda Chang, is a clinician-scientist and Chair of the Medical Department at Brookhaven National Laboratory (BNL). She has been the recipient of two NIH career development awards, first a two-year clinical associate physician (CAP) award through an NCRR-funded General Clinical Research Center (GCRC), followed by a NIDA-funded mentored scientist award for clinicians (K-20) for the past 5 years. She has achieved the intended goals of these NIH career development awards by becoming an independent scientist devoted to patient-oriented research. Specifically, through the mentored K-award, she has developed expertise in several advanced neuroimaging techniques and applied these techniques to study HIV-related brain disorders and drug abuse (cocaine, methamphetamine, and MDMA). Her independence is demonstrated by her receiving three independent research awards that utilize MR techniques to study HIV-associated brain injury and methamphetamine abuse; she is PI on two of these awards (by NINDS and NIDA) and Co-PI on the third award (by NIMH). In addition, she has begun to mentor junior clinician scientists, physicists, computer scientists and chemists, who are pursuing careers in patient-oriented research. She is currently mentoring five clinical scientists (two Assistant Professors and three post-doctoral fellows) and co-mentoring five physicists and computer scientists (three post-doctoral fellows and two pre-doctoral students). In addition, she has active collaborations with many NIDA-funded investigators in drug abuse and/or neuro-HIV research. The current application requests funding (60% salary) for 5-years to ensure that the candidate will have at least 75% protected time to conduct her ongoing research and to continue to mentor the junior clinician scientists. Since Dr. Chang is the Chair of the Medical Department, this award will lead to release of funds from the Department overhead, which will be used to hire an administrative person to minimize her administrative responsibilities. In support of Dr. Chang's career development and research program, BNL has granted her a one-year leave of absence as Chair, in order for her to re-establish her research program at this new location. However, she will need the K-24 award to continue her current level of research and mentoring activities over the next 5 years. In addition to working on the three ongoing R01 funded projects, the candidate plans to obtain additional training in PET, radiotracers and advance fMRI data analyses. This will allow her to develop new approaches to determine how dopaminergic abnormalities might contribute to the functional deficits in drug abuse and/or HIV, using currently available but separate neuroimaging techniques (dopamine studies with PET and BOLD-functional MRI), and taking advantage of the outstanding resources and collaborators at BNL. With the strong publication record, experienced collaborators, and novel approaches, the ongoing projects should be successfully renewed or extended, and lead to new directions in HIV and drug abuse research. ? ? ? ?

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Application #
Study Section
Special Emphasis Panel (ZDA1-KXA-N (19))
Program Officer
Lin, Yu
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Budget End
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Fiscal Year
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University of Hawaii
Internal Medicine/Medicine
Schools of Medicine
United States
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Panee, Jun; Gerschenson, Mariana; Chang, Linda (2018) Associations Between Microbiota, Mitochondrial Function, and Cognition in Chronic Marijuana Users. J Neuroimmune Pharmacol 13:113-122
Castillo, Deborrah; Ernst, Thomas; Cunningham, Eric et al. (2018) Altered Associations between Pain Symptoms and Brain Morphometry in the Pain Matrix of HIV-Seropositive Individuals. J Neuroimmune Pharmacol 13:77-89
Liang, Huajun; Chang, Linda; Chen, Rong et al. (2018) Independent and Combined Effects of Chronic HIV-Infection and Tobacco Smoking on Brain Microstructure. J Neuroimmune Pharmacol 13:509-522
Chang, Linda; Lim, Ahnate; Lau, Eric et al. (2017) Chronic Tobacco-Smoking on Psychopathological Symptoms, Impulsivity and Cognitive Deficits in HIV-Infected Individuals. J Neuroimmune Pharmacol 12:389-401
Wu, Dan; Chang, Linda; Akazawa, Kentaro et al. (2017) Mapping the critical gestational age at birth that alters brain development in preterm-born infants using multi-modal MRI. Neuroimage 149:33-43
Chang, Linda; Løhaugen, Gro C; Andres, Tamara et al. (2017) Adaptive working memory training improved brain function in human immunodeficiency virus-seropositive patients. Ann Neurol 81:17-34
Kogachi, Shannon; Chang, Linda; Alicata, Daniel et al. (2017) Sex differences in impulsivity and brain morphometry in methamphetamine users. Brain Struct Funct 222:215-227
Hayama, Sara; Chang, Linda; Gumus, Kazim et al. (2016) Neural correlates for perception of companion animal photographs. Neuropsychologia 85:278-86
Akazawa, Kentaro; Chang, Linda; Yamakawa, Robyn et al. (2016) Probabilistic maps of the white matter tracts with known associated functions on the neonatal brain atlas: Application to evaluate longitudinal developmental trajectories in term-born and preterm-born infants. Neuroimage 128:167-179
Chang, Linda; Akazawa, Kentaro; Yamakawa, Robyn et al. (2016) Delayed early developmental trajectories of white matter tracts of functional pathways in preterm-born infants: Longitudinal diffusion tensor imaging data. Data Brief 6:1007-15

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