The primary goals of this K24 competing renewal application are to enable Eden Evins, M.D., M.P.H., to 1) conduct career development activities to enhance and extend her patient-oriented addiction research (POAR); and 2) provide intensive and high-quality mentorship to early-career investigators in POAR. A K24 renewal will to give Dr. Evins protected time to devote to career development to increase the impact of her clinical addiction research and to intensive mentoring of junior clinical researchers that would otherwise be spent on clinical and administrative duties. Dr. Evins, Associate Professor of Psychiatry at Harvard Medical School and Director of the Mass General Center for Addiction Medicine, has conducted POAR since 1999, emphasizing studies that integrate different treatment approaches, approach difficult to treat populations and influence clinical practice. Dr. Evins has accomplished the major goals of her initial K24 award. She has mentored over 35 junior investigators, many with K awards, has authored 100 publications, including 42 publications with a mentee as first author. She has conducted a series of studies that have changed clinical practice guidelines for smoking cessation for those with serious mental illness. Dr. Evins? research plan for this renewal application includes continued work as a PI in NIDA funded treatment research, to serve as Co-Investigator on studies with mentees as PI. Further, she plans to submit proposals to 1) expand the scope of smoking cessation treatment for those with serious mental illness to the community, and 2) study effects of cannabis use on psychiatric symptoms, cognitive performance and addiction in those with psychiatric disorders and in adolescents. Dr. Evins? mentoring plan includes training her mentees in 1) clinical aspects of drug abuse; 2) designing and implementing drug abuse research studies; 3) preparing scientific papers and presentations; 4) writing successful grant applications; and 5) responsible conduct of research. She will accomplish this with a combination of individual and group meetings; collaborative mentoring; role modeling; and integrating mentoring with the MGH Division of Clinical Research and the Office of Career Development. Dr. Evins? career development plan involves increasing her expertise in multimodal and optical neuroimaging, assessment of effects of cannabis use in special populations; novel data analytic strategies; and genetics. These activities will both enhance Dr. Evins? research and her mentoring capacity. The public health importance of this application is related to the need to develop new and effective treatments for drug dependent and dually diagnosed patients, and the need to train the next generation of investigators to develop the skills they require to effectively conduct POAR with this patient population.

Public Health Relevance

The primary goals of this K24 competing renewal application are to enable Eden Evins, M.D., M.P.H., to 1) gain specialized expertise through career development to enhance and extend her patient-oriented addiction research; and 2) provide intensive, high-quality mentorship to early-career investigators in patient-oriented research. The public health importance of this application is related to the need to develop new and effective treatments for drug dependent and dually diagnosed patients, and the need to train the next generation of investigators to develop the skills they require to effectively conduct research with this patient population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
2K24DA030443-06
Application #
9180190
Study Section
Addiction Risks and Mechanisms Study Section (ARM)
Program Officer
Aklin, Will
Project Start
2010-09-30
Project End
2021-07-31
Budget Start
2016-08-15
Budget End
2017-07-31
Support Year
6
Fiscal Year
2016
Total Cost
$188,603
Indirect Cost
$13,971
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
Schuster, Randi Melissa; Pachas, Gladys N; Stoeckel, Luke et al. (2018) Phase IIb Trial of an ?7 Nicotinic Receptor Partial Agonist With and Without Nicotine Patch for Withdrawal-Associated Cognitive Deficits and Tobacco Abstinence. J Clin Psychopharmacol 38:307-316
Schuster, Randi Melissa; Gilman, Jodi; Schoenfeld, David et al. (2018) One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory. J Clin Psychiatry 79:
Janes, A C; Gilman, J M; Frederick, B B et al. (2018) Salience network coupling is linked to both tobacco smoking and symptoms of attention deficit hyperactivity disorder (ADHD). Drug Alcohol Depend 182:93-97
Evins, A E; Korhonen, T; Kinnunen, T H et al. (2017) Prospective association between tobacco smoking and death by suicide: a competing risks hazard analysis in a large twin cohort with 35-year follow-up. Psychol Med 47:2143-2154
Schuster, Randi M; Cather, Corinne; Pachas, Gladys N et al. (2017) Predictors of tobacco abstinence in outpatient smokers with schizophrenia or bipolar disorder treated with varenicline and cognitive behavioral smoking cessation therapy. Addict Behav 71:89-95
Schuster, Randi Melissa; Fontaine, Madeleine; Nip, Emily et al. (2017) Prolonged cannabis withdrawal in young adults with lifetime psychiatric illness. Prev Med 104:40-45
Cather, Corinne; Pachas, Gladys N; Cieslak, Kristina M et al. (2017) Achieving Smoking Cessation in Individuals with Schizophrenia: Special Considerations. CNS Drugs 31:471-481
Evins, A Eden; Hoeppner, Susanne S; Schoenfeld, David A et al. (2017) Maintenance pharmacotherapy normalizes the relapse curve in recently abstinent tobacco smokers with schizophrenia and bipolar disorder. Schizophr Res 183:124-129
Janes, A C; Gilman, J M; Radoman, M et al. (2017) Revisiting the role of the insula and smoking cue-reactivity in relapse: A replication and extension of neuroimaging findings. Drug Alcohol Depend 179:8-12
Gilman, Jodi M; Curran, Max T; Calderon, Vanessa et al. (2016) Altered Neural Processing to Social Exclusion in Young Adult Marijuana Users. Biol Psychiatry Cogn Neurosci Neuroimaging 1:152-159

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