Drug abuse and addiction are devastating and chronic conditions that place a significant medical, financial, legal and social burden on our country. Interdisciplinary collaboration combined with technical advances has resulted in unprecedented opportunities to enhance addiction treatment efficacy and durability, and reduce vulnerability to addiction. Continued progress is vital to improving existing evidenced-based treatments and developing new treatments. It is therefore critical to attract and train clinical researchers in order to ensure that a diverse pool of highly skilled scientists will be available to address these urgent health care needs. Dr.
Aim ee McRae-Clark is a productive mid-career investigator who has maintained consistent NIH funding for her innovative work in the area of medications development and gender differences in addictions. In addition, she has a strong track-record of attracting and successfully mentoring medical, graduate and post-doctoral students as well as junior faculty in clinical research focused on substance use disorders, as evidenced by the accomplishments of her previous K24 award. The objective of this Midcareer Investigator Award in Patient-Oriented Research renewal application is to provide support for protected time so that Dr. McRae-Clark can expand her formal, intensive program of mentored clinical research training and career development activities to promote junior scholars in the area of drug abuse and addiction. As in her initial award, particular emphasis will also be placed on increasing the participation of underrepresented minorities, women, and other diverse individuals conducting patient-oriented research. In addition, she will build on her existing program of research by incorporating new proficiencies and research directions, including obtaining further didactic and experiential training in mentorship and leadership skill development; participating in opioid treatment-related initiatives and research; and expanding her work to improve clinical trial remote monitoring technology.

Public Health Relevance

Intensive, mentored clinical training focused on drug abuse and addiction helps ensure that there is a diverse pool of highly trained scientists available to improve treatment outcomes. The objective of this Midcareer Investigator Award in Patient-Oriented Research renewal application is to provide support for protected time so that Dr. Aimee McRae-Clark can continue her formal, intensive program of mentored clinical research training and career development activities to promote junior scholars in the area of drug abuse and addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
2K24DA038240-06
Application #
9744191
Study Section
Interventions to Prevent and Treat Addictions Study Section (IPTA)
Program Officer
Hampson, Aidan
Project Start
2014-08-01
Project End
2024-07-31
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Psychiatry
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29407
Baker, Nathaniel L; Gray, Kevin M; Sherman, Brian J et al. (2018) Biological correlates of self-reported new and continued abstinence in cannabis cessation treatment clinical trials. Drug Alcohol Depend 187:270-277
Bowen, Lynneice L; McRae-Clark, Aimee L (2018) Therapeutic Benefit of Smoked Cannabis in Randomized Placebo-Controlled Studies. Pharmacotherapy 38:80-85
Moran-Santa Maria, Megan M; Sherman, Brian J; Brady, Kathleen T et al. (2018) Impact of endogenous progesterone on reactivity to yohimbine and cocaine cues in cocaine-dependent women. Pharmacol Biochem Behav 165:63-69
Tomko, Rachel L; Baker, Nathaniel L; McClure, Erin A et al. (2018) Incremental validity of estimated cannabis grams as a predictor of problems and cannabinoid biomarkers: Evidence from a clinical trial. Drug Alcohol Depend 182:1-7
Sherman, Brian J; Baker, Nathaniel L; Squeglia, Lindsay M et al. (2018) Approach bias modification for cannabis use disorder: A proof-of-principle study. J Subst Abuse Treat 87:16-22
Moreland, Angela D; McRae-Clark, Aimee (2018) Parenting outcomes of parenting interventions in integrated substance-use treatment programs: A systematic review. J Subst Abuse Treat 89:52-59
Jiang, Wei; Luo, Zhenwu; Martin, Lisa et al. (2018) Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy. Curr HIV Res 16:143-150
Sahlem, Gregory L; Tomko, Rachel L; Sherman, Brian J et al. (2018) Impact of cannabis legalization on treatment and research priorities for cannabis use disorder. Int Rev Psychiatry 30:216-225
Sahlem, Gregory L; Baker, Nathaniel L; George, Mark S et al. (2018) Repetitive transcranial magnetic stimulation (rTMS) administration to heavy cannabis users. Am J Drug Alcohol Abuse 44:47-55
Sherman, Brian J; Baker, Nathaniel L; McRae-Clark, Aimee L (2017) Effect of oxytocin pretreatment on cannabis outcomes in a brief motivational intervention. Psychiatry Res 249:318-320

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