My primary career goals related to this award are: 1) to pursue a program of investigator-initiated, hypothesis driven, high quality patient-oriented research in the specialty of digestive diseases, 2) to mentor young clinicians, with little or no research experience, in their career development as patient-oriented researchers, 3) to continue to mentor and collaborate with other clinical researchers who are beyond the entry level as clinical investigators, and 4) to contribute to career development of GI fellows who are funded on an NIH GI Training Grant. Three research studies support this research and mentoring proposal. These are collaborative research studies currently funded by this K24, the CURE Core Grant, and industry (for PPI's). The first is """"""""Secondary Prevention of Barrett's Epithelium: Pathogenesis, Risk Factors, and Outcomes of Medical or Surgical Therapy"""""""". The principle hypothesis is that medical therapy will be more efficacious and cost effective than laparoscopic fundoplication as secondary prevention in recurrence of Barrett's epithelium. The second is """"""""Development of Risk Scoring Instruments to Predict Outcomes and Probable Bleeding Sites in Patients with Severe Hematochezia"""""""". The primary hypothesis is that a scoring system developed from analysis of large CURE databases of patients with severe hematochezia and based upon clinical variables on presentation can predict outcomes (such as rebleeding and need for endoscopic hemostasis or surgery), and help identify the subgroup of patients most likely to benefit from urgent, sedated colonoscopy. This prospective data collection was funded by recently completed NIH grants. The third study is a feasibility study entitled """"""""Prophylactic Banding or Propranolol to Prevent First Variceal Hemorrhage"""""""". The principle hypothesis is that initial failure of medical therapy (as monitored clinically and by hepatic venous pressure gradient) will be significantly higher and less cost effective than band ligation of varices (as monitored clinically and by endoscopy) in reducing the potential risk of first variceal hemorrhage. The mentoring of young investigators is now through structured masters degree programs and features didactic courses in biostatistics, seminars in study design, and other instruction in data management, form design for prospective trials, and protocol writing. Mentoring emphasis will be placed on planning, designing, and conducting actual prospective randomized studies. This award will continue to enhance the applicant's research productivity and provide skilled mentoring for young investigators, so they can become independent patient-oriented investigators in digestive diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK002650-09
Application #
7265089
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
1999-07-01
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
9
Fiscal Year
2007
Total Cost
$137,193
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Camus, Marine; Khungar, Vandana; Jensen, Dennis M et al. (2016) Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. Dig Dis Sci 61:2732-40
Chavalitdhamrong, Disaya; Jensen, Dennis M; Singh, Bhavneet et al. (2012) Capsule endoscopy is not as accurate as esophagogastroduodenoscopy in screening cirrhotic patients for varices. Clin Gastroenterol Hepatol 10:254-8.e1
Chavalitdhamrong, Disaya; Jensen, Dennis M; Kovacs, Thomas O G et al. (2011) Ischemic colitis as a cause of severe hematochezia: risk factors and outcomes compared with other colon diagnoses. Gastrointest Endosc 74:852-7
Herman, J; Chavalitdhamrong, D; Jensen, D M et al. (2011) The significance of gastric and duodenal histological ischemia reported on endoscopic biopsy. Endoscopy 43:365-8
Jensen, Dennis M; Machicado, Gustavo A (2009) Hemoclipping of chronic canine ulcers: a randomized, prospective study of initial deployment success, clip retention rates, and ulcer healing. Gastrointest Endosc 70:969-75
Jutabha, Rome; Jensen, Dennis M; Chavalitdhamrong, Disaya (2009) Randomized prospective study of endoscopic rubber band ligation compared with bipolar coagulation for chronically bleeding internal hemorrhoids. Am J Gastroenterol 104:2057-64
Ohning, Gordon V; Machicado, Gustavo A; Jensen, Dennis M (2009) Definitive therapy for internal hemorrhoids--new opportunities and options. Rev Gastroenterol Disord 9:16-26
Esrailian, E; Gralnek, I M; Jensen, D et al. (2008) Evaluating the process of care in nonvariceal upper gastrointestinal haemorrhage: a survey of expert vs. non-expert gastroenterologists. Aliment Pharmacol Ther 28:1199-208
Jensen, Dennis M; Machicado, Gustavo A; Hirabayashi, Ken (2006) Randomized controlled study of 3 different types of hemoclips for hemostasis of bleeding canine acute gastric ulcers. Gastrointest Endosc 64:768-73
Jensen, Dennis M; Pace, Samuel C; Soffer, Elaine et al. (2006) Continuous infusion of pantoprazole versus ranitidine for prevention of ulcer rebleeding: a U.S. multicenter randomized, double-blind study. Am J Gastroenterol 101:1991-9; quiz 2170

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