This is a K24 application for Talat Alp Ikizler, M.D. The candidate is faculty at Vanderbilt University Medical Center (VUMC), Division of Nephrology in the """"""""Physician-Scientist"""""""" track with 80 % effort commitment to research. The candidate has focused his research efforts on the elucidation of multiple aspects of nutrition and metabolism in renal failure patients. At the time of this application, the candidate is the principal investigator of 3 federally and 2 non-federally funded grant awards and published 31 manuscripts and 6 book chapters. He is involved in mentoring of 5 past trainees and 3 current trainees. The immediate and long-term objectives of this grant application are to provide protected time for the applicant to focus on research and mentoring activities, specifically facilitate the independence of the current trainees and recruit beginning investigators interested in a rigorous approach to clinical investigation. In addition, the candidate will take a leadership position in clinical research enterprise at the Division of Nephrology. VUMC provides excellent resources for clinical research and mentoring, including the Nephrology Training Grant, Master of Science in Clinical Investigation and Master of Public Health programs (2 current and 1 future trainee enrolled in these programs), General Clinical Research Center and Clinical Nutrition Research Unit. In this proposal, we will investigate three promising approaches to improve the nutritional status of chronic hemodialysis (CHD) patients. First, we will examine the nutritional effects of chronic inflammation on protein and energy metabolism in hemodialysis patients and test the potential beneficial effects of an anti-inflammatory agent on these parameters. Second, we will examine the comparative effectiveness of two nutritional supplementation regimens on protein and energy metabolism in malnourished patients. These protocols will incorporate detailed protein and energy balance studies utilizing stable isotope infusion techniques. In a third study, we will test the hypothesis that recombinant human growth hormone interacts with nutritional supplementation to improve nutritional parameters in 150 CHD patients with overt signs of malnutrition using a prospective, randomized, placebo-controlled study clinical trial.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK062849-05
Application #
7171517
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2003-03-01
Project End
2007-12-31
Budget Start
2007-01-01
Budget End
2007-12-31
Support Year
5
Fiscal Year
2007
Total Cost
$135,683
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Ramer, Sarah J; McCall, Natalie N; Robinson-Cohen, Cassianne et al. (2018) Health Outcome Priorities of Older Adults with Advanced CKD and Concordance with Their Nephrology Providers' Perceptions. J Am Soc Nephrol 29:2870-2878
Parr, Sharidan K; Matheny, Michael E; Abdel-Kader, Khaled et al. (2018) Acute kidney injury is a risk factor for subsequent proteinuria. Kidney Int 93:460-469
Hung, Adriana M; Siew, Edward D; Wilson, Otis D et al. (2018) Risk of Hypoglycemia Following Hospital Discharge in Patients With Diabetes and Acute Kidney Injury. Diabetes Care 41:503-512
Deger, Serpil M; Hung, Adriana M; Gamboa, Jorge L et al. (2017) Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients. JCI Insight 2:
Wild, Marcus G; Wallston, Kenneth A; Green, Jamie A et al. (2017) The Perceived Medical Condition Self-Management Scale can be applied to patients with chronic kidney disease. Kidney Int 92:972-978
Salat, Huzaifah; Javier, Andrei; Siew, Edward D et al. (2017) Nephrology Provider Prognostic Perceptions and Care Delivered to Older Adults with Advanced Kidney Disease. Clin J Am Soc Nephrol 12:1762-1770
Kensinger, Clark; Hernandez, Antonio; Bian, Aihua et al. (2017) Longitudinal assessment of cardiac morphology and function following kidney transplantation. Clin Transplant 31:
Rivara, Matthew B; Yeung, Catherine K; Robinson-Cohen, Cassianne et al. (2017) Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis 69:389-399
Javier, Andrei D; Figueroa, Rocio; Siew, Edward D et al. (2017) Reliability and Utility of the Surprise Question in CKD Stages 4 to 5. Am J Kidney Dis 70:93-101
Zhao, Bixiao; Lu, Qiongshi; Cheng, Yuwei et al. (2017) A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med 195:482-490

Showing the most recent 10 out of 119 publications