EXCEEDTHE SPACE PROVIDED, Susan Greenspan, MD, Professor of Medicine at University of Pittsburgh, is applying for the K24 Midcareer Investigator Award in Patient-Oriented Research to advance her career in clinical investigations of osteoporosis in older men and women. Her immediate career objectives are 1) to establish herself as a leading national authority on osteoporosis in the elderly with a new focus on older men, and 2) to serve as a mentor for medical trainees, including medical students, fellows, and junior faculty members pursuing patient-oriented research in osteoporosis and related geriatric fields. Her long-term objectives are 1) to apply the expertise and skills in patient-oriented osteoporosis research to clinical research in other fields involving common endocrine or geriatric syndromes, and 2) to actively participate in the institutional commitment to promote clinical research at the University of Pittsburgh through mentoring and teaching activities. Dr. Greenspan's research will center on two areas. First, she will explore novel treatments with combination therapy with antiresorptive and anabolic agents for postmenopausal osteoporosis. New techniques assessing outcomes of trabecular vs. cortical bone density and markers of bone turnover will be utilized. Secondly, a model of male osteoporosis will be examined - that of bone loss following androgen deprivation therapy in men with prostate cancer. She will examine the pathophysiology of this bone loss and its prevention. Dr. Greenspan has a strong track record in mentoring junior investigators. This award would ensure protected time for mentoring activities that provide appropriate direction, resources, and educational programs tbr her trainees. Furthermore, this proposal will allow protected time for the candidate's self education for additional training in statistical analysis, the essentials ofmentoring, involvement of African American subjects in clinical research, and leadership in academic medicine for women. The clinical research and mentoring program will be conducted at the University of Pittsburgh, which has a strong institutional commitment to the professional development of the candidate and a mission to support patient-oriented activities of its faculty members. The General Clinical Research Center (Dr. Greenspan's clinical laboratory), the Center for Minority Health, and the recently funded Clinical Research Training Award (K30) will help facilitate this proposal. PERFORMANCESITE( ========================================Section End===========================================

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
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University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
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Perera, Subashan; Nace, David A; Resnick, Neil M et al. (2018) The Nursing Home Physical Performance Test: A Secondary Data Analysis of Women in Long-Term Care Using Item Response Theory. Gerontologist 58:e197-e204
Langmann, Gabrielle A; Perera, Subashan; Ferchak, Mary A et al. (2017) Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc 65:1777-1783
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Michel, Hilary; Olabopo, Flora; Wang, Li et al. (2015) Determinants of 25-Hydroxyvitamin D Concentrations in Infants and Toddlers. Curr Nutr Food Sci 11:124-130
Greenspan, Susan L; Perera, Subashan; Ferchak, Mary Anne et al. (2015) Efficacy and safety of single-dose zoledronic acid for osteoporosis in frail elderly women: a randomized clinical trial. JAMA Intern Med 175:913-21
Greenspan, S L; Vujevich, K T; Brufsky, A et al. (2015) Prevention of bone loss with risedronate in breast cancer survivors: a randomized, controlled clinical trial. Osteoporos Int 26:1857-64
Rajakumar, Kumaravel; Moore, Charity G; Yabes, Jonathan et al. (2015) Effect of Vitamin D3 Supplementation in Black and in White Children: A Randomized, Placebo-Controlled Trial. J Clin Endocrinol Metab 100:3183-92
Rajakumar, Kumaravel; Holick, Michael F; Moore, Charity G et al. (2014) Impact of seasonal flux on 25-hydroxyvitamin D and bone turnover in pre- and early pubertal youth. Pediatr Int 56:35-42
Greenspan, Susan L; Wagner, Julie; Nelson, Joel B et al. (2013) Vertebral fractures and trabecular microstructure in men with prostate cancer on androgen deprivation therapy. J Bone Miner Res 28:325-32

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