? This application request funds for two purposes: ? 1) Career development: the applicant plans to complete an established master's degree program in clinical research at the University of Michigan, Ann Arbor. The career goals include short and long-term goals. Short-term goals include the master's program of study, oversight of mentee during a patient-oriented research project and refinement of a collaborative, multidisciplinary team. The long term goals include assuming a leadership role in clinical research, developing Program Project of Center grant applications, and possibly leading clinical trials network. ? 2) Research Plan: ? -To acquire high-quality neuromuscular signals from the female urethra using concentric needle EMG (with quantitative motor unit analysis) and current perception testing in order to test the null hypotheses that there are no differences in urethral sphincter neuromuscular function in: ? i. Women by race (Caucasian vs. African American), ? ii. Women by continence status (continent vs. incontinent) ? iii. Continent women by parity (parous vs. nulliparous). ? -To collaborate with computer scientists to import these signals into a graphic computer model which accurately reflects our clinical understanding of urethral function ? -To combine urethral and bladder data into the same model and create """"""""rules"""""""" for urethral and bladder interaction. ? b. To model urinary storage in health and disease ? c. To model urinary emptying in health and diseas ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK064044-03
Application #
7095241
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Moen, Laura K
Project Start
2004-09-10
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
3
Fiscal Year
2006
Total Cost
$91,730
Indirect Cost
Name
Loyola University Chicago
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153
Spirka, Thomas; Kenton, Kimberly; Brubaker, Linda et al. (2013) Effect of material properties on predicted vesical pressure during a cough in a simplified computational model of the bladder and urethra. Ann Biomed Eng 41:185-94
Kenton, Kimberly; Mueller, Elizabeth; Brubaker, Linda (2011) Continent women have better urethral neuromuscular function than those with stress incontinence. Int Urogynecol J 22:1479-84