Despite recent progress in obesity prevention, the prevalence of childhood obesity remains at historically high levels. Racial and ethnic minorities and children from disadvantaged backgrounds suffer a disproportionate share of the national obesity burden and these disparities emerge as early as the first two years of life. Many factors contribute to the intractability of obesity but promising approaches for prevention and reduction of related health disparities are emerging including cross-sector strategies that support changes at the individual, family, and systems-levels and which begin in the earliest stages of life. The overall goals of this K24 application are to provide Dr. Elsie Taveras with protected time to perform research to reduce the prevalence of childhood obesity particularly among racial and ethnic minorities and those from disadvantaged backgrounds and to train students, fellows, and junior faculty who wish to perform patient-oriented outcomes research in childhood obesity. Dr. Taveras is an Associate Professor of Pediatrics at Harvard Medical School, Associate Professor of Nutrition at Harvard School of Public Health, and a Pediatrician at Massachusetts General Hospital for Children. She leads several large patient-oriented research studies including an epidemiologic study examining early life origins of childhood obesity disparities; a whole-of-community intervention to prevent obesity among disadvantaged children ages 2-12 years; and a clinical-community intervention to reduce obesity among school-age children. Dr. Taveras has already successfully served as a research mentor to more than a dozen MD and PhD candidates and clinicians in training. This K24 award would come at a critical time in Dr. Taveras's career as it will allow her to heighten research productivity in the area of childhood obesity disparities and help foster the careers of junior childhood obesity scientists through her mentorship. The proposed scientific aims of this K24 application will serve to strengthen Dr. Taveras's ability to provide mentorship to junior investigators in patient-oriented research, with an emphasis on: (a) understanding the early, contextual roots of racial/ethnic and socioeconomic disparities in obesity; (b) attaining broad insights into effective cross-sector strategies for preventing obesity in early life; and (c) translating observational epidemiology int interventions to reduce early life obesity risk factors.

Public Health Relevance

In the US, substantial disparities exist in childhood obesity among racial and ethnic minorities and children from disadvantaged backgrounds. Many factors contribute to the intractability of obesity disparities but promising approaches for prevention and reduction of related health disparities are emerging including multi- sector strategies that begin in the earliest stages of life. The overall goals of this K24 application are to provide Dr. Elsie Taveras with protected time to perform research to reduce childhood obesity and to train students, fellows, and junior faculty who wish to perform patient-oriented outcomes research in childhood obesity disparities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK105989-02
Application #
9116836
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Saslowsky, David E
Project Start
2015-07-28
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
Woo Baidal, Jennifer A; Elbel, Erin E; Lavine, Joel E et al. (2018) Associations of Early to Mid-Childhood Adiposity with Elevated Mid-Childhood Alanine Aminotransferase Levels in the Project Viva Cohort. J Pediatr 197:121-127.e1
Woo Baidal, Jennifer A; Cheng, Erika R; Rifas-Shiman, Sheryl L et al. (2018) Association of vitamin E intake at early childhood with alanine aminotransferase levels at mid-childhood. Hepatology 67:1339-1347
Schiff, Davida M; Wachman, Elisha M; Philipp, Barbara et al. (2018) Examination of Hospital, Maternal, and Infant Characteristics Associated with Breastfeeding Initiation and Continuation Among Opioid-Exposed Mother-Infant Dyads. Breastfeed Med 13:266-274
Fiechtner, Lauren; Perkins, Meghan; Biggs, Vincent et al. (2018) Rationale and design of the Clinic and Community Approaches to Healthy Weight Randomized Trial. Contemp Clin Trials 67:16-22
Fiechtner, Lauren; Cheng, Erika R; Lopez, Gabriel et al. (2017) Multilevel Correlates of Healthy BMI Maintenance and Return to a Healthy BMI among Children in Massachusetts. Child Obes 13:146-153
Taveras, Elsie M; Marshall, Richard; Sharifi, Mona et al. (2017) Comparative Effectiveness of Clinical-Community Childhood Obesity Interventions: A Randomized Clinical Trial. JAMA Pediatr 171:e171325
Taveras, Elsie M; Perkins, Meghan; Anand, Shikha et al. (2017) Clinical effectiveness of the massachusetts childhood obesity research demonstration initiative among low-income children. Obesity (Silver Spring) 25:1159-1166
Freedman, David S; Butte, Nancy F; Taveras, Elsie M et al. (2017) The Limitations of Transforming Very High Body Mass Indexes into z-Scores among 8.7 Million 2- to 4-Year-Old Children. J Pediatr 188:50-56.e1
Sharifi, Mona; Franz, Calvin; Horan, Christine M et al. (2017) Cost-Effectiveness of a Clinical Childhood Obesity Intervention. Pediatrics 140:
Freedman, David S; Butte, Nancy F; Taveras, Elsie M et al. (2017) BMI z-Scores are a poor indicator of adiposity among 2- to 19-year-olds with very high BMIs, NHANES 1999-2000 to 2013-2014. Obesity (Silver Spring) 25:739-746

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