Type 2 diabetes is a major public health concern, particularly in older adults. There are major gaps in our knowledge about diabetes in the elderly. In older adults, there is controversy regarding the total burden of risk associated with diabetes, optimal treatment targets, and how best to reduce cardiovascular risk and prevent cognitive and physical impairment. Novel biomarkers of diabetes and cardiovascular disease reflect the summation of acute and chronic morbidity and may have utility for informing treatment decisions but they have not been rigorously evaluated in older adults in the community. To address these issues we need junior patient-oriented investigators who will need rigorous training and mentorship in the areas of clinical epidemiology, translational research methods, and the conduct of large clinical studies including randomized clinical trials. The candidate, Elizabeth Selvin, PhD, MPH, has devoted her career to the study of the clinical epidemiology of type 2diabetes and the mentorship of trainees in this field. This midcareer award will protect the time of the candidate for research and mentoring. The goals of the project are to characterize diabetes incidence and progression in older adults, evaluate diabetes awareness and barriers to self-care and treatment adherence, and to examine the prognostic value of novel biomarkers for risk stratification. We will also evaluate the comparative response of traditional and novel cardiometabolic biomarkers to a glucose-lowering intervention in a randomized clinical trial of persons with type 2 diabetes. These projects will provide a rich substrate for training and new research opportunities for mentees. Dr. Selvin has a strong track record of success in the field and in mentoring junior scientists. With support from this K24, Dr. Selvin will be able to expand her mentorship activities, strengthen her research portfolio, and recruit and train the next generation of leaders in the field.

Public Health Relevance

The goal of this project is to provide support for mentoring and research in the clinical epidemiology of type 2 diabetes. Dr. Selvin has a strong track record of success in the field and in mentoring junior scientists. With support from this K24, Dr. Selvin will be able to expand her mentorship activities, strengthen her research portfolio, and recruit and train the next generation of leaders in the field.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK106414-05
Application #
9697810
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Spain, Lisa M
Project Start
2015-07-15
Project End
2021-05-31
Budget Start
2019-06-01
Budget End
2021-05-31
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Mondul, Alison M; Joshu, Corinne E; Barber, John R et al. (2018) Longer-term Lipid-lowering Drug Use and Risk of Incident and Fatal Prostate Cancer in Black and White Men in the ARIC Study. Cancer Prev Res (Phila) 11:779-788
Schneider, Andrea L C; Zhao, Di; Lutsey, Pamela L et al. (2018) Serum Vitamin D Concentrations and Cognitive Change Over 20 Years: The Atherosclerosis Risk in Communities Neurocognitive Study. Neuroepidemiology 51:131-137
Poon, Anna K; Meyer, Michelle L; Reaven, Gerald et al. (2018) Short-Term Repeatability of Insulin Resistance Indexes in Older Adults: The Atherosclerosis Risk in Communities Study. J Clin Endocrinol Metab 103:2175-2181
Ding, Ning; Kwak, Lucia; Ballew, Shoshana H et al. (2018) Traditional and nontraditional glycemic markers and risk of peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis 274:86-93
Selvin, Elizabeth; Warren, Bethany; He, Xintong et al. (2018) Establishment of Community-Based Reference Intervals for Fructosamine, Glycated Albumin, and 1,5-Anhydroglucitol. Clin Chem 64:843-850
Jung, Molly; Warren, Bethany; Grams, Morgan et al. (2018) Performance of non-traditional hyperglycemia biomarkers by chronic kidney disease status in older adults with diabetes: Results from the Atherosclerosis Risk in Communities Study. J Diabetes 10:276-285
Hicks, Caitlin W; Yang, Chao; Ndumele, Chiadi E et al. (2018) Associations of Obesity With Incident Hospitalization Related to Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study. J Am Heart Assoc 7:e008644
Warren, Bethany; Lee, Alexandra K; Ballantyne, Christie M et al. (2018) Diagnostic Performance of 1,5-Anhydroglucitol Compared to 2-H Glucose in the Atherosclerosis Risk in Communities Study. Clin Chem 64:1536-1537
Walker, Keenan A; Windham, B Gwen; Power, Melinda C et al. (2018) The association of mid-to late-life systemic inflammation with white matter structure in older adults: The Atherosclerosis Risk in Communities Study. Neurobiol Aging 68:26-33
Saeed, Anum; Nambi, Vijay; Sun, Wensheng et al. (2018) Short-Term Global Cardiovascular Disease Risk Prediction in Older Adults. J Am Coll Cardiol 71:2527-2536

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