The goal of this proposed midcareer investigator award is to expand training in multi-disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will expand current research efforts and develop a mentoring program with trainees from several relevant disciplines. This program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a continuation of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that particulate matter air pollution exerts its effect through systemic oxidative stress and inflammation, which in turn results in endothelial dysfunction. The first project studies the effect of diesel exhaust particulate on endothelial function in controlled inhalational exposures, addressing mechanistic hypotheses to understand the role of systemic oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on plasma markers of endothelial activation, oxidative stress, and systemic inflammation in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, pulmonary medicine, allergy, and cardiology; medical students; and graduate students in epidemiology, toxicology, occupational and environmental hygiene, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24ES013195-01A1
Application #
6966749
Study Section
Special Emphasis Panel (ZES1-LKB-A (K7))
Program Officer
Shreffler, Carol K
Project Start
2005-09-01
Project End
2010-07-31
Budget Start
2005-09-01
Budget End
2006-07-31
Support Year
1
Fiscal Year
2005
Total Cost
$149,067
Indirect Cost
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Honda, Trenton; Eliot, Melissa N; Eaton, Charles B et al. (2017) Long-term exposure to residential ambient fine and coarse particulate matter and incident hypertension in post-menopausal women. Environ Int 105:79-85
Bell, Griffith; Mora, Samia; Greenland, Philip et al. (2017) Association of Air Pollution Exposures With High-Density Lipoprotein Cholesterol and Particle Number: The Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 37:976-982
Kulick, Erin R; Wellenius, Gregory A; Kaufman, Joel D et al. (2017) Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study). Stroke 48:1966-1968
D'Souza, Jennifer C; Kawut, Steven M; Elkayam, Laura R et al. (2017) Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis. Environ Health Perspect 125:077019
Sack, Coralynn; Vedal, Sverre; Sheppard, Lianne et al. (2017) Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air-lung study. Eur Respir J 50:
Gepner, Adam D; Young, Rebekah; Delaney, Joseph A et al. (2017) Comparison of Carotid Plaque Score and Coronary Artery Calcium Score for Predicting Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 6:
Liu, Rui; Young, Michael T; Chen, Jiu-Chiuan et al. (2016) Ambient Air Pollution Exposures and Risk of Parkinson Disease. Environ Health Perspect 124:1759-1765
Aaron, Carrie P; Chervona, Yana; Kawut, Steven M et al. (2016) Particulate Matter Exposure and Cardiopulmonary Differences in the Multi-Ethnic Study of Atherosclerosis. Environ Health Perspect 124:1166-73
Pang, Yuanjie; Peng, Roger D; Jones, Miranda R et al. (2016) Metal mixtures in urban and rural populations in the US: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study. Environ Res 147:356-64

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