This midcareer investigator award (K24) will provide protected time, resources, and structure that will allow for a progression in my research career trajectory, from a primary focus on HIV prevention, to a more inclusive and extensive conceptualization of prevention in the broader context of sexual and reproductive health (SRH). Further, it will allow me to engage in a comprehensive process of mentorship in the use of mixed methodologies in patient-oriented research. My career development goals are to: 1) expand my knowledge and expertise from HIV prevention alone to a more inclusive focus on sexual and reproductive health, 2) advance an expanded research agenda into the development of effective sexual and reproductive health technologies and interventions, and 3) advance my scholarly role in the use of mixed methods research for health promotion sciences by mentoring fellows and junior investigators in patient oriented research. The proposed mentorship plan will allow me to dedicate the necessary time and effort to fully integrate a comprehensive mixed methods research training program into my mentoring of junior investigators. The proposed research will provide the context for mentoring those investigators. The structured mentorship program will allow me to provide scientific leadership and in-depth methodological training for junior investigators interested in prevention intervention and treatment evaluation research. Through this mentorship in state-of-the-science mixed methods, I will promote the conduct of rigorous health promotion research across a wide range of health promotion sciences. My midcareer development plan will allow me to pursue learning and research activities that broaden my knowledge base and expertise into SRH and help me to better understand user experiences with SRH technologies, and identify those factors that impact use. Critical to use is """"""""acceptability."""""""" However, current conceptualizations of adherence and acceptability fail to fully articulate and account for patterns of use and non-use. I propose that a new model of use, """"""""Effective Use,"""""""" is required, and propose the conduct of a longitudinal prospective mixed methods study to articulate this model. The concept of """"""""Effective Use"""""""" begins with an inherent demand for the best user experience. It holds that a user's positive experience drives use, and that because use is maintained by this positive experience, higher exposure to the biomedical intervention (e.g., active ingredient), whether for prevention or treatment, is achieved. Relevance to Public Health: Sexual and reproductive health is a global public health priority. Providing efficacious SRH technologies that have the greatest likelihood of use will have the greatest impact on women's health. If successful, an Effective Use model would offer a new paradigm for the development of sexual and reproductive health technologies for women and their partners that will result in increased use and improved sexual and reproductive health outcomes.

Public Health Relevance

This K24 award will provide me with protected time to conduct mixed methods research that will articulate a new paradigm for the development of sexual and reproductive health technologies: specific to my research, our ability to develop technologies that have the greatest likelihood of use will have the greatest impact on women's sexual and reproductive health, a global public health priority. The K24 award will also allow time to implement a comprehensive mixed methods mentorship program to train a new cadre of researchers in the health promotion sciences

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Developmental Biology Subcommittee (CHHD)
Program Officer
Newcomer, Susan
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Miriam Hospital
United States
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Guthrie, Kate M; Rosen, Rochelle K; Vargas, Sara E et al. (2018) User evaluations offer promise for pod-intravaginal ring as a drug delivery platform: A mixed methods study of acceptability and use experiences. PLoS One 13:e0197269
Underhill, Kristen; Guthrie, Kate M; Colleran, Christopher et al. (2018) Temporal Fluctuations in Behavior, Perceived HIV Risk, and Willingness to Use Pre-Exposure Prophylaxis (PrEP). Arch Sex Behav 47:2109-2121
Kuo, Caroline; LoVette, Ashleigh; Stein, Dan J et al. (2018) Building resilient families: Developing family interventions for preventing adolescent depression and HIV in low resource settings. Transcult Psychiatry :1363461518799510
Merrill, Jennifer E; Rosen, Rochelle K; Walker, Susan B et al. (2018) A qualitative examination of contextual influences on negative alcohol consequence evaluations among young adult drinkers. Psychol Addict Behav 32:29-39
Cioe, Patricia A; Guthrie, Kate M; Freiberg, Matthew S et al. (2018) Cardiovascular Risk Reduction in Persons Living With HIV: Treatment Development, Feasibility, and Preliminary Results. J Assoc Nurses AIDS Care 29:163-177
Thorsen, Margaret M; Patena, John V; Guthrie, Kate Morrow et al. (2018) Using High-Risk Adolescents' Voices to Develop a Comprehensible Cognitive Behavioral Therapy-Based Text-Message Program. Behav Med 44:89-99
Guthrie, Kate M; Rosen, Rochelle K; Vargas, Sara E et al. (2017) User input in iterative design for prevention product development: leveraging interdisciplinary methods to optimize effectiveness. Drug Deliv Transl Res 7:761-770
Weld, Ethel D; Hiruy, Hiwot; Guthrie, Kate Morrow et al. (2017) A Comparative Pre-Phase I Study of the Impact of Gel Vehicle Volume on Distal Colon Distribution, User Experience, and Acceptability. AIDS Res Hum Retroviruses 33:440-447
Guthrie, Kate Morrow; Dunsiger, Shira; Vargas, Sara E et al. (2016) Perceptibility and the ""Choice Experience"": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design. AIDS Res Hum Retroviruses 32:1022-1030
Choo, Esther; Guthrie, K Morrow; Mello, Michael et al. (2016) ""I need to hear from women who have 'been there'"": Developing a woman-focused intervention for drug use and partner violence in the emergency department. Partner Abuse 7:193-220

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