This Midcareer Investigator Award in Patient-Oriented Research application focuses on training and mentoring of cardiovascular imaging techniques (i.e., echocardiography, cardiac MRI, and positron emission tomography) for the study of mechanisms of disease in patients with cardiovascular diseases. The goals are: 1) to continue the mentoring program of cardiology fellows established by the applicant, 2) to continue patient-oriented research in the applicant's laboratory, and 3) for the applicant to acquire additional training and skills in cardiac MRI. The applicant-PI has an established record of mentoring young investigators, and will use this grant as a mechanism to further mentoring of young investigators, and will use this grant as a mechanism to further the mentoring of young investigators in the use of non-invasive cardiovascular imaging techniques to answer clinically relevant questions through hypothesis-testing. Young trainees will be exposed to ongoing clinical investigations that use novel methods and techniques to explore mechanisms of human disease in a multi-disciplinary environment. The main themes of investigation of the applicant include elucidation of the relationship between myocardial blood flow, contractile function and metabolic function in various disease states such as hypertensive heart disease and heart failure. The applicant will continue to develop a clinical research program that builds upon recent developments in this area by our group and others. This multi- disciplinary approach to elucidate mechanisms of human disease in clinical medicine include the use of clinical and quantitative tools for hypothesis testing. Trainee support is obtained through several mechanisms: The Cardiovascular Division's NIH Training Grant, the NIH's Minority Investigator Research Supplements, the AHA, and private foundations (Fourjay, Dana, Doris Duke, and Robert Wood Johnson). Trainees will formulate hypothesis that require quantitative characterization of cardiovascular pathophysiology through the acquisition and processing of multi-imaging data, and test them through the use and application of biostatistical methods. The ultimate goal of the PI is to expand the training program of cardi9logy fellows that want o become independent clinician-scientists. A funded research program that illustrates the research program for young investigators is described, to illustrate the applicant's involvement in mentoring in patient-oriented research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24HL067002-04
Application #
6901097
Study Section
Special Emphasis Panel (ZHL1-CSR-F (O1))
Program Officer
Scott, Jane
Project Start
2002-07-01
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
4
Fiscal Year
2005
Total Cost
$130,380
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
de las Fuentes, Lisa; Gu, C Charles; Mathews, Santhosh J et al. (2008) Osteopontin promoter polymorphism is associated with increased carotid intima-media thickness. J Am Soc Echocardiogr 21:954-60
Waggoner, Alan D; De Las Fuentes, Lisa; Faddis, Mitchell N et al. (2008) Left ventricular diastolic filling prior to cardiac resynchronization therapy: implications for atrioventricular delay programming. Pacing Clin Electrophysiol 31:838-44
Gu, C Charles; Flores, Hubert R; de las Fuentes, Lisa et al. (2008) Enhanced detection of genetic association of hypertensive heart disease by analysis of latent phenotypes. Genet Epidemiol 32:528-38
Rochat, R H; de las Fuentes, L; Stormo, G et al. (2007) A novel method combining linkage disequilibrium information and imputed functional knowledge for tagSNP selection. Hum Hered 64:243-9
Rovner, Aleksandr; Waggoner, Alan D; Mathews, Santhosh J et al. (2007) Role of tissue Doppler and color M-mode imaging for evaluation of diastolic function in ambulatory patients with LV systolic dysfunction. Echocardiography 24:478-84
Rovner, Aleksandr; de Las Fuentes, Lisa; Faddis, Mitchell N et al. (2007) Relation of left ventricular lead placement in cardiac resynchronization therapy to left ventricular reverse remodeling and to diastolic dyssynchrony. Am J Cardiol 99:239-41
Waggoner, Alan D; Rovner, Aleksandr; de las Fuentes, Lisa et al. (2006) Clinical outcomes after cardiac resynchronization therapy: importance of left ventricular diastolic function and origin of heart failure. J Am Soc Echocardiogr 19:307-13
Rovner, Aleksandr; de las Fuentes, Lisa; Waggoner, Alan D et al. (2006) Characterization of left ventricular diastolic function in hypertension by use of Doppler tissue imaging and color M-mode techniques. J Am Soc Echocardiogr 19:872-9
Peterson, Linda R; Waggoner, Alan D; de las Fuentes, Lisa et al. (2006) Alterations in left ventricular structure and function in type-1 diabetics: a focus on left atrial contribution to function. J Am Soc Echocardiogr 19:749-55
Narayan, Sanjiv M; Smith, Joseph M; Lindsay, Bruce D et al. (2006) Relation of T-wave alternans to regional left ventricular dysfunction and eccentric hypertrophy secondary to coronary heart disease. Am J Cardiol 97:775-80

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