Anxiety disorders are among the most common and troublesome mental illnesses affecting children and adolescents. While the field has made considerable progress in developing empirically supported treatments for these conditions, the anxiety disorders still lag far behind the disruptive behavior disorders with respect to treatment research. One reason is that there are too few researchers with sufficient exposure to both cognitive-behavioral and pharmacological treatment interventions for anxious children, as well as the tenets and methods used in complex clinical trials and studies of mechanisms of improvement. As one of the few researchers, my chief aim is to use time liberated by this Independent Scientist Award (ISA) to develop, evaluate and disseminate new diagnostic and treatment approaches for the pediatric anxiety disorders. To this end, the ISA career development plan (1) further my knowledge of complex statistical procedures, evidence-based medicine and understanding of ethics in research, and (2), emphasizes knowledge dissemination, including a proposed T32 training grant focused on the treatment of pediatric mental disorders. The ISA research plan centers on ongoing and proposed NIMH- funded treatment outcome studies in Obsessive-Compulsive Disorder (OCD) and Post-traumatic Stress Disorder (PTSD). As with the preparatory Scientist Development Award for Clinicians (SDAC), the ISA will advance sustained practical and theoretical contributions to my chosen research area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH001557-04
Application #
6477009
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Program Officer
Sherrill, Joel
Project Start
1998-12-15
Project End
2003-11-30
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
4
Fiscal Year
2002
Total Cost
$108,412
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
March, John S (2011) The preschool ADHD Treatment Study (PATS) as the culmination of twenty years of clinical trials in pediatric psychopharmacology. J Am Acad Child Adolesc Psychiatry 50:427-30
March, John S (2011) Looking to the future of research in pediatric anxiety disorders. Depress Anxiety 28:88-98
March, John S (2010) Commentary on 'Forum: use of antidepressants in children and adolescents'. Curr Opin Psychiatry 23:63-5
March, J S; Vitiello, B (2009) Benefits exceed risks of newer antidepressant medications in youth--maybe. Clin Pharmacol Ther 86:355-7
Shapiro, Mark; Silva, Susan G; Compton, Scott et al. (2009) The child and adolescent psychiatry trials network (CAPTN): infrastructure development and lessons learned. Child Adolesc Psychiatry Ment Health 3:12
March, John S; Klee, Brian J; Kremer, Charlotte M E (2006) Treatment benefit and the risk of suicidality in multicenter, randomized, controlled trials of sertraline in children and adolescents. J Child Adolesc Psychopharmacol 16:91-102
March, John S; Silva, Susan G; Compton, Scott et al. (2005) The case for practical clinical trials in psychiatry. Am J Psychiatry 162:836-46
March, John S; Chrisman, Allan; Breland-Noble, Alfiee et al. (2005) Using and teaching evidence-based medicine: the Duke University child and adolescent psychiatry model. Child Adolesc Psychiatr Clin N Am 14:273-96, viii-ix
March, John S; Silva, Susan G; Compton, Scott et al. (2004) The Child and Adolescent Psychiatry Trials Network (CAPTN). J Am Acad Child Adolesc Psychiatry 43:515-8
Kondo, Douglas G; Chrisman, Allan K; March, John S (2003) An evidence-based medicine approach to combined treatment for ADHD in children and adolescents. Psychopharmacol Bull 37:7-23

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