Abstract

This Midcareer Investigator Award in Patient-Oriented Research (K24) application is in response to program announcement (PA-99-133) """"""""Career Development Awards: Child Abuse and Neglect Research."""""""" Pediatric maltreatment-related PTSD is associated with dysregulation of biological stress systems, adverse brain maturation, and medial prefrontal cortical dysfunction. Building on previous work in developmental traumatology, the aim of this K24 is to investigate the psychobiology of effective PTSD treatment for sexually-abused children. The objectives of the career development plan are to: 1) develop expertise in evidence-based psychosocial treatments i.e., cognitive behavioral therapy (CBT) and combined psychopharmacologic interventions for maltreated children with PTSD, 2) further the candidate's knowledge of developmental and cognitive neuroscience emphasizing the integration and translation of brain imaging measurement as it relates to neurodiagnostic assessment and treatment, 3) increase the candidate's practical and empirical knowledge in the conduct and design of relevant clinical trials for treatment development including advanced research design, methodology and statistical aspects of conducting longitudinal studies and clinical trials, and 4) emphasize knowledge dissemination of the translational components of this research by mentoring junior colleagues in child abuse and neglect research. The research plan is linked to an ongoing study using brain imaging to help elucidate neurobiological markers in sexually abused children with PTSD. The objective of the research plan is a CBT treatment study using non-invasive biological markers (24 hour urinary concentrations of cortisol and catecholamines, MRS-based brain NAA concentrations of medial prefrontal cortex, and measures of neuropsychological functioning), in a pre-post design to investigate the pathogenesis of PTSD in 30 sexually abused children, ages 6 to 12 years. Exploring these biological markers in trauma-focused CBT + Sertraline and CBT + placebo is also proposed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH071434-03
Application #
7225587
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Boyce, Cheryl A
Project Start
2005-05-01
Project End
2010-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
3
Fiscal Year
2007
Total Cost
$145,413
Indirect Cost

  Institution

Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Nooner, Kate B; Hooper, Stephen R; De Bellis, Michael D (2018) An examination of sex differences on neurocognitive functioning and behavior problems in maltreated youth. Psychol Trauma 10:435-443
Stave, Elise A; De Bellis, Michael D; Hooper, Steven R et al. (2017) Dimensions of Attention Associated With the Microstructure of Corona Radiata White Matter. J Child Neurol 32:458-466
Morey, Rajendra A; Haswell, Courtney C; Hooper, Stephen R et al. (2016) Amygdala, Hippocampus, and Ventral Medial Prefrontal Cortex Volumes Differ in Maltreated Youth with and without Chronic Posttraumatic Stress Disorder. Neuropsychopharmacology 41:791-801
Urger, Sacide E; De Bellis, Michael D; Hooper, Stephen R et al. (2015) The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates. J Child Neurol 30:9-20
De Bellis, Michael D; Hooper, Stephen R; Chen, Steven D et al. (2015) Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder. Dev Psychopathol 27:1555-76
Crozier, Joseph C; Wang, Lihong; Huettel, Scott A et al. (2014) Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter? Dev Psychopathol 26:491-513
Hooper, Stephen R; Woolley, Donald; De Bellis, Michael D (2014) Intellectual, neurocognitive, and academic achievement in abstinent adolescents with cannabis use disorder. Psychopharmacology (Berl) 231:1467-77
Marcus Jenkins, Jade V; Woolley, Donald P; Hooper, Stephen R et al. (2013) Direct and Indirect Effects of Brain Volume, Socioeconomic Status and Family Stress on Child IQ. J Child Adolesc Behav 1:
De Bellis, Michael D; Wang, Lihong; Bergman, Sara R et al. (2013) Neural mechanisms of risky decision-making and reward response in adolescent onset cannabis use disorder. Drug Alcohol Depend 133:134-45
Urger, Efsun; Debellis, Michael D; Hooper, Steven R et al. (2013) Influence of analysis technique on measurement of diffusion tensor imaging parameters. AJR Am J Roentgenol 200:W510-7

Showing the most recent 10 out of 26 publications