The purpose of this 5-year award is to build upon the unique multidisciplinary training of the principle investigator in patient-oriented research pertaining to translational research in complex chronic disease, and strengthen her ability to guide the next generation of scholars. Specifically, with this award the investigator will: (1) Expand her content expertise pertaining to mobile- and web-based applications useful for translational research. (2) Develop and pilot test a new web-supported lifestyle management intervention in those with chronic kidney disease. (3) Serve as a mentor for trainees and junior faculty members pursuing patient-oriented research activities and careers pertaining to translational research in those with multimorbidity. (4) Institutionalize her program of research by developing a P30 application to support a Center on Translational Research in Multimorbidity.

Public Health Relevance

The number of people with chronic illness is growing and projected to reach 171 million by the year 2030, and almost 1/2 of those with a chronic disease have multiple chronic conditions. However, the literature on self-management has been derived mainly from empirical work in prevention or populations with uncomplicated disease and employ interventions that target a single behavior. This application is designed to further the candidate's patient-oriented translational research in multimorbidity. The award will provide the applicant with sufficient protected time to accomplish the following aims: (1) mentor the next generation of researchers, (2) engage in a mid-career shift to incorporate web-based interventions into her research, (3) develop and implement a pilot study using a web-based intervention in chronic kidney disease patients, and (4) develop a P30 application to institutionalize her research program with a Center for Translational Research in Multimorbidity.

National Institute of Health (NIH)
National Institute of Nursing Research (NINR)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
National Institute of Nursing Research Initial Review Group (NRRC)
Program Officer
Roary, Mary
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New York University
Internal Medicine/Medicine
Schools of Medicine
New York
United States
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Hu, Lu; St-Jules, David E; Popp, Collin J et al. (2018) Determinants and the Role of Self-Efficacy in a Sodium-Reduction Trial in Hemodialysis Patients. J Ren Nutr :
Sevick, Mary Ann; Woolf, Kathleen; Mattoo, Aditya et al. (2018) The Healthy Hearts and Kidneys (HHK) study: Design of a 2×2 RCT of technology-supported self-monitoring and social cognitive theory-based counseling to engage overweight people with diabetes and chronic kidney disease in multiple lifestyle changes. Contemp Clin Trials 64:265-273
St-Jules, David E; Jagannathan, Ram; Gutekunst, Lisa et al. (2017) Examining the Proportion of Dietary Phosphorus From Plants, Animals, and Food Additives Excreted in Urine. J Ren Nutr 27:78-83
Jagannathan, Ram; Seixas, Azizi; St-Jules, David et al. (2017) Systems Biology Genetic Approach Identifies Serotonin Pathway as a Possible Target for Obstructive Sleep Apnea: Results from a Literature Search Review. Sleep Disord 2017:6768323
St-Jules, David E; Goldfarb, David S; Pompeii, Mary Lou et al. (2017) Phosphate Additive Avoidance in Chronic Kidney Disease. Diabetes Spectr 30:101-106
Jagannathan, Ram; Sevick, Mary Ann; Li, Huilin et al. (2016) Elevated 1-hour plasma glucose levels are associated with dysglycemia, impaired beta-cell function, and insulin sensitivity: a pilot study from a real world health care setting. Endocrine 52:172-5
St-Jules, David E; Goldfarb, David S; Sevick, Mary Ann (2016) Nutrient Non-equivalence: Does Restricting High-Potassium Plant Foods Help to Prevent Hyperkalemia in Hemodialysis Patients? J Ren Nutr 26:282-7
Sevick, Mary Ann; Piraino, Beth M; St-Jules, David E et al. (2016) No Difference in Average Interdialytic Weight Gain Observed in a Randomized Trial With a Technology-Supported Behavioral Intervention to Reduce Dietary Sodium Intake in Adults Undergoing Maintenance Hemodialysis in the United States: Primary Outcomes of t J Ren Nutr 26:149-58
St-Jules, David E; Woolf, Kathleen; Pompeii, Mary Lou et al. (2016) Exploring Problems in Following the Hemodialysis Diet and Their Relation to Energy and Nutrient Intakes: The BalanceWise Study. J Ren Nutr 26:118-24
St-Jules, David E; Woolf, Kathleen; Pompeii, Mary Lou et al. (2016) Reexamining the Phosphorus-Protein Dilemma: Does Phosphorus Restriction Compromise Protein Status? J Ren Nutr 26:136-40

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