Increased intracranial pressure (ICP) is a serious complication in head injury and other neurologic conditions. Increased ICP compromises the cerebral circulation and can lead to permanent ischemic damage or death. Measurement of ICP forms the basis of rational therapy aimed at controlling its level. Such measurements are invasive and involve implanting transducers or catheters within-the cranium. A method for determining the ICP without having to implant measurement devices would be of considerable interest in the neurosurgical and neurological intensive care. It would be useful to have a non-invasive test and monitoring method to measure the ICP in a variety of conditions such as head injury, intracerebral hemorrhage, subarachnoid hemorrhage, pseudotumor cerebri, hydrocephalus and shunt obstruction, as well as in other conditions. The central theme of this proposal is to develop a method to estimate intracranial pressure (ICP) non-invasively. Transcranial Doppler (TCD) can be used to continuously record blood flow velocity from the intracranial vessels which then can be used in combination with arterial blood pressure (ABP) recording to measure the vascular tone and overall resistance in the cerebrovascular bed, which can be used to estimate intracranial pressure. We propose to utilize this information to establish the scientific principles to calculate intracranial pressure non-invasively from TCD and ABP measurements. We then propose to test this method for accuracy of continuous recording of ICP under ICU conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24NS002128-02
Application #
6393175
Study Section
NST-2 Subcommittee (NST)
Program Officer
Jacobs, Tom P
Project Start
2000-09-20
Project End
2004-11-30
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
2
Fiscal Year
2001
Total Cost
$111,126
Indirect Cost
Name
University of Washington
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Sviri, Gill E; Aaslid, Rune; Douville, Colleen M et al. (2009) Time course for autoregulation recovery following severe traumatic brain injury. J Neurosurg 111:695-700
Aaslid, Rune; Blaha, Martin; Sviri, Gill et al. (2007) Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli. Stroke 38:1465-9
Suppiramaniam, Vishnu; Vaithianathan, Thirumalini; Parameshwaran, Kodeeswaran (2006) Electrophysiological analysis of interactions between carbohydrates and transmitter receptors reconstituted in lipid bilayers. Methods Enzymol 417:80-90
Aaslid, Rune; Lash, Stephanie R; Bardy, Gust H et al. (2003) Dynamic pressure--flow velocity relationships in the human cerebral circulation. Stroke 34:1645-9
Park, Cheol Wan; Sturzenegger, Mathias; Douville, Colleen M et al. (2003) Autoregulatory response and CO2 reactivity of the basilar artery. Stroke 34:34-9
Newell, David W; Schuster, James M; Avellino, Anthony M (2002) Intracranial-to-intracranial vascular anastomosis created using a microanastomotic device for the treatment of distal middle cerebral artery aneurysms. Technical note. J Neurosurg 97:486-91