This application for a Midcareer Investigator Award in Patient Oriented Research (K24) seeks support for an investigator who is committed to excellent research in human nutrition, and especially to mentoring future leaders in Pediatric Nutrition. The objective of this application is to enable the candidate to solidify and expand her efforts in patient oriented research, and to foster her ability to mentor clinical investigators and other trainees in Pediatric Nutrition. The candidate has an excellent record of conducting patient oriented research, which has been funded by both federal and non-federal sources, In the course of her academic career to date, she has mentored more than 25 pre- and post-doctoral trainees, currently including 2 physician clinical fellows and 2 post-doctoral fellows, all of whom are conducting research projects directly relevant to Pediatric Nutrition. The candidate's research focus is zinc (Zn) homeostasis in normal but vulnerable populations, including infants, children, and women during the reproductive cycle, and in pathologic conditions in which Zn homeostasis may be perturbed. An emerging area of research interest for the candidate and for trainees in Pediatric Nutrition is pediatric obesity prevention and treatment. Three funded patient oriented research projects are described in this application: investigations to characterize secretion of intestinal endogenous Zn and its potential modulation by metallothionein; a large scale intervention trial examining the effects of phytate-reduced maize on maternal reproductive outcomes and Zn homeostasis in Guatemalan women, and on growth and trace mineral status of their breastfed infants; and a pilot study examining Zn status and Zn excretion in relation to insulin sensitivity in severely obese adolescents. The specific mentoring aims are 1) to develop a structured, rigorous training program for post-doctoral fellows and other trainees in Pediatric Nutrition through newly created courses and training sessions, which will be linked with existing resources in the broader UCHSC academic community; and 2) to aggressively recruit outstanding trainees, especially physicians, to the field of Pediatric Nutrition to develop a larger cohort of physician nutrition specialist leaders in this area. This award will substantially contribute to the candidate's Career goals by enabling her to relinquish some clinical, educational and administrative duties in order to better focus on patient oriented research in Pediatric Nutrition, and by enhancing her ability to mentor the next generation of clinical investigators.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24RR018357-02
Application #
6865451
Study Section
Nutrition Study Section (NTN)
Program Officer
Wilde, David B
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
2
Fiscal Year
2005
Total Cost
$87,832
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Young, B E; Levek, C; Reynolds, R M et al. (2018) Bioactive components in human milk are differentially associated with rates of lean and fat mass deposition in infants of mothers with normal vs. elevated BMI. Pediatr Obes 13:598-606
Hambidge, K Michael; Miller, Leland V; Mazariegos, Manolo et al. (2017) Upregulation of Zinc Absorption Matches Increases in Physiologic Requirements for Zinc in Women Consuming High- or Moderate-Phytate Diets during Late Pregnancy and Early Lactation. J Nutr 147:1079-1085
Hambidge, K Michael; Mazariegos, Manolo; Kindem, Mark et al. (2012) Infant stunting is associated with short maternal stature. J Pediatr Gastroenterol Nutr 54:117-9
Miller, Leland V; Sheng, Xiao-Yang; Hambidge, K Michael et al. (2010) The use of dysprosium to measure endogenous zinc excretion in feces eliminates the necessity of complete fecal collections. J Nutr 140:1524-8
Krebs, Nancy F; Gao, Dexiang; Gralla, Jane et al. (2010) Efficacy and safety of a high protein, low carbohydrate diet for weight loss in severely obese adolescents. J Pediatr 157:252-8
Mazariegos, Manolo; Hambidge, K Michael; Westcott, Jamie E et al. (2010) Neither a zinc supplement nor phytate-reduced maize nor their combination enhance growth of 6- to 12-month-old Guatemalan infants. J Nutr 140:1041-8
Sheng, Xiao-Yang; Hambidge, K Michael; Miller, Leland V et al. (2009) Measurement of zinc absorption from meals: comparison of extrinsic zinc labeling and independent measurements of dietary zinc absorption. Int J Vitam Nutr Res 79:230-7
Rosado, Jorge L; Hambidge, K Michael; Miller, Leland V et al. (2009) The quantity of zinc absorbed from wheat in adult women is enhanced by biofortification. J Nutr 139:1920-5
Hambidge, K Michael; Miller, Leland V; Westcott, Jamie E et al. (2008) Dietary reference intakes for zinc may require adjustment for phytate intake based upon model predictions. J Nutr 138:2363-6
Miller, Leland V; Krebs, Nancy F; Hambidge, K Michael (2007) A mathematical model of zinc absorption in humans as a function of dietary zinc and phytate. J Nutr 137:135-41

Showing the most recent 10 out of 16 publications