The candidate for the proposed """"""""Mentored Quantitative Research Career Award"""""""" has multidisciplinary training and research experience in polymer chemistry and materials science. His expertise in the field of polymer chemistry, material science and vibrational spectroscopy has placed him in a unique position to apply this strong knowledge base to the area of biomaterials and biomedical/tissue engineering. The program outlined in this career development application adds a biological/clinical foundation to the candidate's background. The candidate will build his research knowledge, experience and understanding of the biological aspects of oral tissue development, disease processes involving oral and craniofacial tissues, and molecular biologic techniques through a multidisciplinary program that combines education, mentoring and completion of an innovative research study. The candidate's long-term goal is to establish himself as a productive, independent research scientist in biomaterials/tissue engineering with a specific focus on the development of replacement materials for oral and craniofacial tissues. Research activities will be completed in the newly created Center for Research in Interfacial Structure and Properties at the UMKC School of Dentistry. A fundamental goal of the Center, which is under the direction of the candidate's mentors: Drs. Paulette Spencer and J. Lawrence Katz, is to provide a research environment that serves as a catalyst for collaborative investigations focused on applying the principles of biological systems to the hierarchal design, synthesis and application of biomaterials. The candidate proposes to use novel high-resolution analytical techniques for direct in situ detection of the molecular structure and micro-mechanics of the bond formed at the adhesive interface with caries-affected dentin and sclerotic dentin. The work will identify the structure/property characteristics that inhibit the formation of a durable bond at the adhesive interface with these clinically relevant dentin substrates. Results from this work will provide critical, new insight into failure mechanisms at the dentin/adhesive interface; failure that can ultimately lead to premature breakdown of the composite restoration.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
1K25DE015281-01
Application #
6669963
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
Hardwick, Kevin S
Project Start
2003-08-01
Project End
2008-05-31
Budget Start
2003-08-01
Budget End
2004-05-31
Support Year
1
Fiscal Year
2003
Total Cost
$113,268
Indirect Cost
Name
University of Missouri Kansas City
Department
Dentistry
Type
Schools of Dentistry
DUNS #
010989619
City
Kansas City
State
MO
Country
United States
Zip Code
64110
Xu, Changqi; Wang, Yong (2012) Collagen cross linking increases its biodegradation resistance in wet dentin bonding. J Adhes Dent 14:11-8
Hechler, Benjamin; Yao, Xiaomei; Wang, Yong (2012) Proanthocyanidins alter adhesive/dentin bonding strengths when included in a bonding system. Am J Dent 25:276-80
Xu, Changqi; Wang, Yong (2012) Chemical composition and structure of peritubular and intertubular human dentine revisited. Arch Oral Biol 57:383-91
Karan, Kunal; Yao, Xiaomei; Xu, Changqi et al. (2012) Chemical characterization of etched dentin in non-carious cervical lesions. J Adhes Dent 14:315-22
Xu, Changqi; Wang, Yong (2011) Cross-linked demineralized dentin maintains its mechanical stability when challenged by bacterial collagenase. J Biomed Mater Res B Appl Biomater 96:242-8
Green, Bradley; Yao, Xiaomei; Ganguly, Arindam et al. (2010) Grape seed proanthocyanidins increase collagen biodegradation resistance in the dentin/adhesive interface when included in an adhesive. J Dent 38:908-15
Wang, Yong; Yao, Xiaomei (2010) Morphological/chemical imaging of demineralized dentin layer in its natural, wet state. Dent Mater 26:433-42
Ye, Qiang; Wang, Yong; Spencer, Paulette (2009) Nanophase separation of polymers exposed to simulated bonding conditions. J Biomed Mater Res B Appl Biomater 88:339-48
Shin, T Phillip; Yao, Xiaomei; Huenergardt, Robin et al. (2009) Morphological and chemical characterization of bonding hydrophobic adhesive to dentin using ethanol wet bonding technique. Dent Mater 25:1050-7
Karan, Kunal; Yao, Xiaomei; Xu, Changqi et al. (2009) Chemical profile of the dentin substrate in non-carious cervical lesions. Dent Mater 25:1205-12

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