The long-term research goal of this Career Development Award is to develop a predictor of sleep apnea based on a combination of family history score and 3-dimensional cone-beam Computer Tomography (CT) morphological variables. In the course of this matched case-control research study, we will collect these variables from 30 confirmed severe sleep apnea patients and 30 gender, age and Body Mass Index matched controls. The confounders in this study are race, ethnicity and hypertension. The goal is to identify which combination of the CT and family history variables are risk factors for sleep apnea in a population of severe sleep apnea (RDI>30). This is the first step to our long-term goal of being able to identify patients at risk for incipient and mild-moderate sleep apnea from a younger population who are being referred for a cone-beam CT during the course of their dental or medical treatment. To the imaging data we can easily add a personal and family history questionnaire on snoring and OSA. If we are successful at identifying early as being at risk for sleep apnea, behavioral changes and/or minor surgery can change the development of the disease, avoiding congestive heart failure and other heart diseases such as pulmonary hypertension, cardiac arrhythmia, ischemic heart disease and stroke. With 2-4% of the middle-aged population in North America affected by Obstructive Sleep Apnea (OSA), sleep apnea is more prevalent among the obese, in males, and in older individuals. With obesity increasing dramatically in the USA, this is a timely research area. According to the National Sleep Foundation 28% of men and 24% of women over the age of 65 have sleep apnea. It is estimated that, in the U.S. alone, $70 billion is lost in decreased productivity, lost wages, and property damage due to snoring and sleep disorders. ? ? The Career Development Plan includes two years of enrollment in the """"""""Masters of clinical and ? biomedical investigations"""""""" under the research direction of Dr. Azen, Professor and Co-Director of ? Biostatistics in the Department of Preventive Medicine at the University of Southern California (USC), with the 3rd and 4th years focusing on collecting and analyzing the data under the research direction of Dr. Clark, Professor and Director of the Orofacial Pain/Oral Medicine Graduate Clinic at USC and expert on sleep disturbance and temporomandibular joint disorders. The 5th year's focus will be on report and grant writing. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
1K25DE016391-01A1
Application #
6983314
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
Hardwick, Kevin S
Project Start
2005-09-30
Project End
2009-08-31
Budget Start
2005-09-30
Budget End
2006-08-31
Support Year
1
Fiscal Year
2005
Total Cost
$109,318
Indirect Cost
Name
University of Southern California
Department
Dentistry
Type
Schools of Dentistry
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Shigeta, Yuko; Ogawa, Takumi; Tomoko, Ikawa et al. (2013) Soft palate length and upper airway relationship in OSA and non-OSA subjects. Tex Dent J 130:203-11
Enciso, Reyes; Shigeta, Yuko; Nguyen, Manuel et al. (2012) Comparison of cone-beam computed tomography incidental findings between patients with moderate/severe obstructive sleep apnea and mild obstructive sleep apnea/healthy patients. Oral Surg Oral Med Oral Pathol Oral Radiol 114:373-81
Shigeta, Yuko; Ogawa, Takumi; Ando, Eriko et al. (2011) Influence of tongue/mandible volume ratio on oropharyngeal airway in Japanese male patients with obstructive sleep apnea. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:239-43
Enciso, Reyes; Clark, Glenn T (2011) Comparing the Berlin and the ARES questionnaire to identify patients with obstructive sleep apnea in a dental setting. Sleep Breath 15:83-9
Kartalian, Armine; Gohl, Elizabeth; Adamian, Melina et al. (2010) Cone-beam computerized tomography evaluation of the maxillary dentoskeletal complex after rapid palatal expansion. Am J Orthod Dentofacial Orthop 138:486-92
Zhao, Ying; Nguyen, Manuel; Gohl, Elizabeth et al. (2010) Oropharyngeal airway changes after rapid palatal expansion evaluated with cone-beam computed tomography. Am J Orthod Dentofacial Orthop 137:S71-8
Enciso, Reyes; Nguyen, Manuel; Shigeta, Yuko et al. (2010) Comparison of cone-beam CT parameters and sleep questionnaires in sleep apnea patients and control subjects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:285-93
Shigeta, Yuko; Ogawa, Takumi; Tomoko, Ikawa et al. (2010) Soft palate length and upper airway relationship in OSA and non-OSA subjects. Sleep Breath 14:353-8
Chung, Jin Woo; Enciso, Reyes; Levendowski, Daniel J et al. (2010) Patients with positional versus nonpositional obstructive sleep apnea: a retrospective study of risk factors associated with apnea-hypopnea severity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110:605-10
Gohl, Elizabeth; Nguyen, Manuel; Enciso, Reyes (2010) Three-dimensional computed tomography comparison of the maxillary palatal vault between patients with rapid palatal expansion and orthodontically treated controls. Am J Orthod Dentofacial Orthop 138:477-85

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