application) Mark A. Schnitzler, Ph. D., is a health economist with particular interest in renal transplantation. This K25 proposal is designed to enhance Dr. Schnitzler's knowledge of the practice of renal transplant medicine coupled with a research project examining the clinical and economic efficiency of cadaveric kidney allocation. The combination of these educational and research elements are designed to position Dr. Schnitzler to make important contributions to the study of renal transplantation as his career progresses. The educational portion of this project will use the resources of the nephrology and renal transplantation fellowships and the graduate curriculum of the Medical School at Washington University in St. Louis, Missouri to expose Dr. Schnitzler to the science and practice of renal transplant medicine. The program includes weekly observation of clinical practice during the first three years of the project and participation in the nephrology and renal transplant fellowship educational conference series for the full five years of the project. Graduate courses covering medical ethics and immunology will be taken throughout the five years of the project. The research program for this project examines the efficiency of various possible alternatives to the current cadaveric kidney allocation system. Little integrated study exists jointly examining the clinical and economic implications of organ allocation. There are four aims that cover: 1) the identification of alternative allocation systems; 2) the estimation of outcomes associated with allocation criteria; 3) estimation of the distributional characteristics of allocation systems; and 4) estimation of the relative potential clinical and economic results of alternative cadaveric kidney allocation systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
7K25DK002916-04
Application #
6756442
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2001-05-01
Project End
2006-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
4
Fiscal Year
2004
Total Cost
$131,898
Indirect Cost
Name
Saint Louis University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
050220722
City
Saint Louis
State
MO
Country
United States
Zip Code
63103
Machnicki, G; Pinsky, B; Takemoto, S et al. (2009) Predictive ability of pretransplant comorbidities to predict long-term graft loss and death. Am J Transplant 9:494-505
Burroughs, Thomas E; Swindle, Jason P; Salvalaggio, Paolo R et al. (2009) Increasing incidence of new-onset diabetes after transplant among pediatric renal transplant patients. Transplantation 88:367-73
Neri, Luca; Rocca Rey, Lisa A; Pinsky, Brett W et al. (2008) Increased risk of graft failure in kidney transplant recipients after a diagnosis of dyspepsia or gastroesophageal reflux disease. Transplantation 85:344-52
Machnicki, Gerardo; Ricci, Jean-Francois; Brennan, Daniel C et al. (2008) Economic impact and long-term graft outcomes of mycophenolate mofetil dosage modifications following gastrointestinal complications in renal transplant recipients. Pharmacoeconomics 26:951-67
Bunnapradist, Suphamai; Neri, Luca; Wong, Wendy et al. (2008) Incidence and risk factors for diarrhea following kidney transplantation and association with graft loss and mortality. Am J Kidney Dis 51:478-86
Burroughs, Thomas E; Lentine, Krista L; Takemoto, Steve K et al. (2007) Influence of early posttransplantation prednisone and calcineurin inhibitor dosages on the incidence of new-onset diabetes. Clin J Am Soc Nephrol 2:517-23
Burroughs, Thomas E; Swindle, Jason; Takemoto, Steven et al. (2007) Diabetic complications associated with new-onset diabetes mellitus in renal transplant recipients. Transplantation 83:1027-34
Stirnemann, Paula M; Takemoto, Steven K; Schnitzler, Mark A et al. (2006) Agreement of immunosuppression regimens described in Medicare pharmacy claims with the Organ Procurement and Transplantation Network survey. J Am Soc Nephrol 17:2299-306
Lentine, Krista L; Schnitzler, Mark A; Abbott, Kevin C et al. (2006) Incidence, predictors, and associated outcomes of atrial fibrillation after kidney transplantation. Clin J Am Soc Nephrol 1:288-96
Bunnapradist, Suphamai; Lentine, Krista L; Burroughs, Thomas E et al. (2006) Mycophenolate mofetil dose reductions and discontinuations after gastrointestinal complications are associated with renal transplant graft failure. Transplantation 82:102-7

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