The candidate's primary interest is to understand the reorganization and recruitment associated with sensorimotor learning in healthy and stroke populations. The proposed research will test two primary hypotheses: 1) that a relatively new brain imaging technique, diffuse optical tomography (DOT), is able to detect and map learning-related modulations in brain function, and 2) that learning-related modulations in primary and secondary motor cortices are larger - both spatially and in amplitude - and less lateralized in hemiparetic stroke patients than the changes in these regions in control subjects. To test these hypotheses, the research project will first characterize and validate the DOT technique by employing simultaneous DOT and functional magnetic resonance imaging (fMRI) as both healthy and patient volunteers perform motor tasks. The fMRI activation maps will serve as a spatial """"""""gold standard"""""""" to which the simultaneously acquired optical imaging maps will be co-registered and compared. Comparisons will be performed within and between populations, with data analysis enhanced by models of the physiological noise in the DOT recordings as well as tuning of DOT image reconstruction algorithms. We expect this approach to provide a validated technique for detecting hemodynamic changes in the brain with the advantages of portability, unobtrusiveness, low cost, and spectroscopic information. The final component of the research plan will be a pilot application of DOT brain imaging during a gait re-acquisition task. This DOT application will be performed in a rehabilitation setting, infeasible for other brain imaging methods. In conjunction with the proposed research plan, the candidate seeks training in one primary and one secondary area. The primary area of training will be in stroke: The etiology and consequences thereof, associated rehabilitation, as well as general patient-focused research methods. The secondary area will cover cutting-edge DOT image reconstruction and data analysis techniques. Completion of this training will allow the candidate to pursue an independent research program in basic and clinical neuroscience addressing questions related to functional brain reorganization in healthy and patient populations. Importantly, use of the DOT technology in such a research program is expected to enable the investigation of tasks and populations that are otherwise beyond the reach of existing brain imaging technologies. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
1K25NS046554-01
Application #
6675768
Study Section
NST-2 Subcommittee (NST)
Program Officer
Pancrazio, Joseph J
Project Start
2003-07-15
Project End
2008-03-31
Budget Start
2003-07-15
Budget End
2004-03-31
Support Year
1
Fiscal Year
2003
Total Cost
$146,070
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
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Strangman, Gary E; Goldstein, Richard; O'Neil-Pirozzi, Therese M et al. (2009) Neurophysiological alterations during strategy-based verbal learning in traumatic brain injury. Neurorehabil Neural Repair 23:226-36
Strangman, Gary E; O'Neil-Pirozzi, Therese M; Goldstein, Richard et al. (2008) Prediction of memory rehabilitation outcomes in traumatic brain injury by using functional magnetic resonance imaging. Arch Phys Med Rehabil 89:974-81
Weiss, Anthony P; Duff, Margaret; Roffman, Joshua L et al. (2008) Auditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigation. Neuroreport 19:161-5
Zhang, Quan; Brown, Emery N; Strangman, Gary E (2007) Adaptive filtering to reduce global interference in evoked brain activity detection: a human subject case study. J Biomed Opt 12:064009
Zhang, Quan; Brown, Emery N; Strangman, Gary E (2007) Adaptive filtering for global interference cancellation and real-time recovery of evoked brain activity: a Monte Carlo simulation study. J Biomed Opt 12:044014
Strangman, Gary; Goldstein, Richard; Rauch, Scott L et al. (2006) Near-infrared spectroscopy and imaging for investigating stroke rehabilitation: test-retest reliability and review of the literature. Arch Phys Med Rehabil 87:S12-9
Strangman, Gary; Thompson, John H; Strauss, Monica M et al. (2005) Functional brain imaging of a complex navigation task following one night of total sleep deprivation: a preliminary study. J Sleep Res 14:369-75
Strangman, Gary; O'Neil-Pirozzi, Therese M; Burke, David et al. (2005) Functional neuroimaging and cognitive rehabilitation for people with traumatic brain injury. Am J Phys Med Rehabil 84:62-75
Strangman, Gary; Heindel, William C; Anderson, James A et al. (2005) Learning motor sequences with and without knowledge of governing rules. Neurorehabil Neural Repair 19:93-114