This project is aimed at developing new simulation capabilities for elucidating the hemodynamics in intracranial aneurysms. Successful completion of this project will create a systematic and methodical approach to the determination of function in intracranial aneurysms and will provide important new guidance to clinicians as they develop strategies to treat these disorders.
The specific aims of these projects are therefore: 1) To determine the impact of experimental imprecision in the specification of CFD models on the computed velocity fields 2) To develop CFD modeling capabilities for predicting regions of intra-luminal thrombus deposition 3) To initiate numerical simulations of flow in a number of patient-specific cerebral aneurysm geometries and initiate a study of the role of hemodynamic descriptors in aneurysm progression. Current advances in medical imaging and computational methods provide an opportunity to use numerical modeling for investigation of the flow in intracranial aneurysms on a patient-specific basis. We propose to combine the state of the art medical imaging with 3D visualization and computational fluid dynamics methods to accurately capture the flow physics and its implications on the aneurysm progression. The objective of this project is to develop a CFD tool for estimating the velocity field in aneurysmal vessels in vivo, and to establish the range of validity of that tool. Relevance to public health: This proposal aims to develop computational methods for assessing blood flow patterns within cerebral aneurysms. These developments will provide the tools needed to determine the impact of flow-related forces to the progression of aneurysmal disease. They will also provide the ability to predict the likely outcome of different surgical interventions, and will provide clinicians with the ability to determine the most effective strategy for treating these disorders. The ability to simulate blood flow patterns in intracranial aneurysms should provide new insights into the underlying physiology that causes some aneurysms to remain stable, and others to grow, resulting in profound symptoms or rupture with a high likelihood of devastating cerebral injury or death.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Mentored Quantitative Research Career Development Award (K25)
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NST-2 Subcommittee (NST)
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Koenig, James I
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University of California San Francisco
Schools of Medicine
San Francisco
United States
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Sigovan, Monica; Rayz, Vitaliy; Gasper, Warren et al. (2013) Vascular remodeling in autogenous arterio-venous fistulas by MRI and CFD. Ann Biomed Eng 41:657-68
Boutchko, Rostyslav; Rayz, Vitaliy L; Vandehey, Nicholas T et al. (2012) Imaging and modeling of flow in porous media using clinical nuclear emission tomography systems and computational fluid dynamics. J Appl Geophy 76:74-81
Boussel, Loic; Rayz, Vitaliy; Martin, Alastair et al. (2011) Temporal stability of dysmorphic fusiform aneurysms of the intracranial internal carotid artery. J Vasc Interv Radiol 22:1007-11
Leach, Joseph R; Rayz, Vitaliy L; Mofrad, Mohammad R K et al. (2010) An efficient two-stage approach for image-based FSI analysis of atherosclerotic arteries. Biomech Model Mechanobiol 9:213-23
Rayz, V L; Boussel, L; Ge, L et al. (2010) Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms. Ann Biomed Eng 38:3058-69
Leach, Joseph R; Rayz, Vitaliy L; Soares, Bruno et al. (2010) Carotid atheroma rupture observed in vivo and FSI-predicted stress distribution based on pre-rupture imaging. Ann Biomed Eng 38:2748-65
Boussel, Loic; Rayz, Vitaliy; Martin, Alastair et al. (2009) Phase-contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: comparison with computational fluid dynamics. Magn Reson Med 61:409-17
Rayz, V L; Boussel, L; Lawton, M T et al. (2008) Numerical modeling of the flow in intracranial aneurysms: prediction of regions prone to thrombus formation. Ann Biomed Eng 36:1793-804
Boussel, Loic; Rayz, Vitaliy; McCulloch, Charles et al. (2008) Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study. Stroke 39:2997-3002