This Award will provide support for the establishment and operation of a core facility for mouse cardiovascular phenotyping. It will also support three projects with implications for aging research: 1) adult-onset cardiomyopathy in mice; 2) age-induced placental insufficiency in mice; and 3) functional tumor vasculogenic mimicry. The application includes specific plans to mentor young investigators who select careers in translational cardiovascular research. Specific long-term career goals: 1) Operate an internationally recognized cardiovascular mouse phenotyping core facility; 2) advance the understanding of the cellular basis of heritable dilated cardiomyopathy, and develop diagnostic and therapeutic modalities with the potential for clinical application; 3) determine the nature and magnitude of impairment of maternal-placental circulation in murine disease states which recapitulate important clinical conditions, and develop therapeutic strategies which have potential for clinical application; 4) apply newfound knowledge about the function of tumor vasculogenic mimicry channels toward improved cancer diagnosis and treatment; and 5) develop and implement a training program in translational mouse cardiovascular research, dedicated toward fostering the careers of future independent investigators. These goals will be pursued by application of current methods and development of new methods for investigation of mouse cardiovascular function in vivo. The project will initially rely on ultrasonography and cardiac catheterization to achieve its Specific Aims. During the course of the Award, new methods for cardiovascular studies in mice will be tested and implemented. Ultimately, the information gained by these studies in mice will form the foundation for the development of novel and feasible advances in the diagnosis and treatment of patients with cardiovascular disorders.
| He, B Julie; Joiner, Mei-Ling A; Singh, Madhu V et al. (2011) Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med 17:1610-8 |
| Miller, Jordan D; Weiss, Robert M; Serrano, Kristine M et al. (2010) Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease. Arterioscler Thromb Vasc Biol 30:2482-6 |
| Miller, Jordan D; Peotta, Veronica A; Chu, Yi et al. (2010) MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. Am J Physiol Heart Circ Physiol 298:H1600-7 |
| Michele, Daniel E; Kabaeva, Zhyldyz; Davis, Sarah L et al. (2009) Dystroglycan matrix receptor function in cardiac myocytes is important for limiting activity-induced myocardial damage. Circ Res 105:984-93 |
| Berry, Christopher J; Miller, Jordan D; McGroary, KellyAnn et al. (2009) Biventricular adaptation to volume overload in mice with aortic regurgitation. J Cardiovasc Magn Reson 11:27 |
| Miller, Jordan D; Weiss, Robert M; Serrano, Kristine M et al. (2009) Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 119:2693-701 |
| Kobayashi, Yvonne M; Rader, Erik P; Crawford, Robert W et al. (2008) Sarcolemma-localized nNOS is required to maintain activity after mild exercise. Nature 456:511-5 |
| Morgan, Donald A; Thedens, Daniel R; Weiss, Robert et al. (2008) Mechanisms mediating renal sympathetic activation to leptin in obesity. Am J Physiol Regul Integr Comp Physiol 295:R1730-6 |
| Shi, Peijun P; Cao, Xiao R; Sweezer, Eileen M et al. (2008) Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol 295:F462-70 |
| Halabi, Carmen M; Beyer, Andreas M; de Lange, Willem J et al. (2008) Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab 7:215-26 |
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