The applicant seeks support for a midcareer investigator to conduct intensive mouse immunopathology research using comparative pathology approach and to mentor beginning investigators in mouse pathbiology research. Dr. Chen Liu is a board-certified surgical pathologist. He is an Associate Professor, the Director of Gastrointestinal and Liver Pathology Service, and the Director of GI/Liver Pathology Fellowship training program. Dr. Liu is actively engaged in clinical patient care, basic and translational research using mouse models, and mentoring clinical fellows, residents, postdoctoral fellows, graduate students, and undergraduate students. Dr. Liu's primary research focus is immunopathology of hepatitis C viral infection, which is currently supported by NIH grants. His team has established novel mouse models to investigate immune responses in viral infection. In this proposal, he will study the T cell response and the function of regulatory T cells in HCV infection. He will test novel strategies to harness the immune response against HCV infection. Dr. Liu's research group consists of very talented young postdoctoral research fellows, graduate students, residents/follows, medical student, and undergraduate student. The goal is to mentor beginning investigators to become future investigators who have the expertise in both mouse and human immunopathology. In addition, Dr. Liu has established international collaborations on mouse immuopathology research. Through these studies, Dr. Liu has established himself as an expert in comparative mouse immunopathology. Over the past 8 years, Dr. Liu has co-authored 63 peer-reviewed articles and 9 book chapters/reviews. Within the Institution, Dr. Liu is a well-established pathologist who has expertise in both human and mouse systems. He is involved in research projects on autoimmune diseases using mouse models. Because of these extensive ongoing research activities, Dr. Liu intends to have dedicated time to train new investigators who will fill the growing need of mouse pathologist in biomedical research. The University of Florida has a comprehensive animal care facility with 169,026 square feet of space that hosts more than 350 strains of mice and 1,400 approved research protocols. With additional collaborations locally and nationally, the institution will provide an outstanding environment for Dr. Liu's career development and mentoring next generation of mouse pathobiologists. The K26 midcareer award is an excellent mechanism to support Dr. Liu to achieve this goal.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Midcareer Investigator Award in Biomedical and Behavioral Research (K26)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Mirochnitchenko, Oleg
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Florida
Schools of Medicine
United States
Zip Code
Zhao, Xiangxuan; Puszyk, William M; Lu, Zaiming et al. (2015) Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma. Mol Cancer Ther 14:80-9
Sheng, Weian; Ogunwobi, Olorunseun O; Chen, Tao et al. (2014) Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip. Lab Chip 14:89-98
Zhao, Xiangxuan; Tian, Changhai; Puszyk, William M et al. (2013) OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma. Lab Invest 93:8-19
Ogunwobi, Olorunseun O; Puszyk, William; Dong, Hui-Jia et al. (2013) Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma. PLoS One 8:e63765
Liu, Hongyan; Trinh, Thu Le; Dong, Huijia et al. (2012) Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus. PLoS One 7:e46631
Ogunwobi, Olorunseun O; Liu, Chen (2012) Therapeutic and prognostic importance of epithelial-mesenchymal transition in liver cancers: insights from experimental models. Crit Rev Oncol Hematol 83:319-28
Jeung, Jennifer A; Coran, Justin J; Liu, Chen et al. (2012) Hepatocyte paraffin 1 antigen as a biomarker for early diagnosis of Barrett esophagus. Am J Clin Pathol 137:111-20
Jeung, Jennifer; Patel, Roshan; Vila, Lizette et al. (2012) Quantitation of HER2/neu expression in primary gastroesophageal adenocarcinomas using conventional light microscopy and quantitative image analysis. Arch Pathol Lab Med 136:610-7
Pan, Jen-Jung; Oh, Seh-Hoon; Soldevila-Pico, Consuelo et al. (2011) Low prevalence of HBV DNA in the liver allograft from anti-HBc-positive donors: a single-center experience. Clin Transplant 25:164-70
Cao, Mengde; Xu, Yiling; Youn, Je-in et al. (2011) Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model. Lab Invest 91:598-608

Showing the most recent 10 out of 11 publications