Statethe application'sbroad, long-termobjectivesand specificaims, making referenceto the health relatednessof the project.Describeconciselythe researchdesignand methodsfor achievingthesegoals.Avoidsummariesof pastaccomplishmentsand the useof the firstperson. This abstractis meantto serveas a succinct andaccuratedescriptionof the proposedwork when separatedfrom the application. Iftheapplicationis funded,this description,as is, will becomepublic information.Therefore,do not include proprietary/confidentiailnformation. DONOT EXCEED THE SPACE PROVIDED. Translation of basic biomedical discoveries depends critically upon the availability of a highly skilled clinicalresearch workforce. In 1998, with funds from the NIH K30 program, the Mayo Clinical Research Training Program(CRTP) was launched. A comprehensive didactic curriculum was developed and integrated with structured mentor-based research practicums. Within 5 years CRTP became the most successful program at Mayo Graduate School: 108enrollees and 27 graduates to date. Our excellent progress includes: development of more interactive and advancedcoursework; a highly qualified faculty with outstanding track records in both research and training; a robust and effectiveorganizational structure; excellent scholar outcomes (9 publications & $440,000 extramural funding per graduate);23 intramural and 14 NIH research training/career development awards (including Research on Research IntegrityRO1NS044527), a research training collaboration with a minority-serving institution (R25RR17589), and surveydata showing >93% major improvement, among CRTP scholars, in each of 12 clinical research core competencies. Over the next funding cycle we will build on this success and provide further enhancements. Through a process ofcomprehensive curriculum review combined with detailed assessment of the future of biomedicine, new and moreadvanced curricular offerings have been designed. These include: GCRC-based human studies methodologies;Clinical Genomics; Bioinformatics and Medical Informatics; Systematic Reviews and Meta-analysis; Regulatory Issuesin Clinical Research (emphasizing patient privacy and restoring the public's trust); and Research with MinorityPopulations. New initiatives have been developed for: scholars' career development (eg. a monthly forum wherescholars network with established clinical investigators to discuss career challenges/opportunities); enhanced facultyeffectiveness (tailored faculty development programs, a 'Guide for CRTP mentors' defining mentor, scholar andprogram expectations, and new faculty awards); and innovative evaluation tools centered on clinical research corecompetencies, including a novel course evaluation system which actively engages scholars in the synthesis andcommunication of course and program evaluation. Finally, the CRTP enjoys strong institutional commitment andpowerful synergies with Mayo Clinic's outstanding, well-established clinical practice, education and researchprograms (e.g. GCRC). Together, these characteristics will ensure that CRTP graduates are optimally preparedto translate bioloaical discoveries into improvements in health.PERFORMANCE SITE(S) (organization, city, state) Mayo Clinic Rochester Rochester, MinnesotaKEY PERSONNEL. See instructions. Use continuationpages as neededto provide the required information in the format shown below.Start with Principal Investigator. List all other key personnel in alphabetical order, last name first.Name Organization Role on ProjectGabriel, Sherine E., MD, MSc Mayo Clinic Program DirectorCamilleri, Michael, MD Mayo Clinic Co-DirectorBallman, Karla V., PhD Mayo Clinic Associate DirectorCerhan, James R., MD, PhD Mayo Clinic Associate DirectorViggiano, Thomas R., MD Mayo Clinic ConsultantDisclosure Permission StatemenL Applicable to SBIR/STTR Only. See instructions. [] Yes [] NoPHS 398 (Rev. 05/01) Page 2 Numberpagesconsecutivelaytthebottomthroughout Form Page 2 theapplicationD. onotusesuffixesuchas2a,2b.CO Principal Investigator/Program Director (Last, first, middle): Gabriel, Sherine E., MD, MScCLINICAL RESEARCH CURRICULUM AWARD (K-30)Competing Renewal
| Krause, Megan L; Crowson, Cynthia S; Michet, C John et al. (2016) Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013. Arthritis Rheumatol 68:247-54 |
