This proposal outlines research and training to occur with funding from a Pathway to Independence Award (K99/R00). The training objective during the first two years of the award is to foster training in neuroimaging and human behavioral assessment to prepare me for a translational research career in academia, and accelerate my progress towards independence. During the K99 phase, I will complete research projects with the following goals: (1) determine the utility of olfactory function measures for distinguishing children with prenatal alcohol exposure (PAE) from non-exposed typically developing control children (CON) and children with idiopathic attention deficit/hyperactivity disorder (ADHD);and (2) understand the neural dissimilarities in these groups of children that contribute to their behavior. I will undertake an intensive training regimen to obtain the necessary expertise to conduct neuroimaging research. I will also begin studies using functional magnetic resonance imaging (fMRI) to investigate differences in central olfactory processing systems in PAE, ADHD and CON children. I will promote my career development by attending relevant seminars and scientific conferences, publishing my research findings, and interviewing for independent faculty positions. The proposed mentors, Drs. Edward Riley, Claire Murphy, and Jay Giedd are experts in the fetal alcohol spectrum disorders, chemical senses, and pediatric neurodevelopment fields, respectively. The collaborative research and training environments at the Center for Behavioral Teratology, San Diego State University, and University of California, San Diego will provide me with the necessary resources to complete the aims outlined in this proposal. In the 3-year R00 phase of the award, I will establish myself in my new role as an independent researcher and continue my research on olfactory functioning in children with PAE and ADHD with the following goals: (1) examine the relationship between attention deficits, olfactory function, neural activation patterns and stimulant treatment responses;and (2) determine the value of olfactory function measures in predicting chronic responses to psychostimulant treatments in children with PAE using a mouse-model. The work described in this proposal is in line with NIAAA's mission for """"""""improving diagnosis of FASD, increasing the understanding of the effects of alcohol on the unborn child, and developing effective interventions to mitigate the health effects on those prenatally exposed to alcohol.""""""""
The proposed project will help researchers and clinicians better understand the behavioral and neural consequences of prenatal alcohol exposure. The information gained from this research can be used to aid in clinical diagnosis, the development of novel treatments and refinement of current pharmacologic interventions for children with Fetal Alcohol Spectrum Disorders.
|Doyle, Lauren R; Moore, Eileen M; Coles, Claire D et al. (2018) Executive Functioning Correlates With Communication Ability in Youth With Histories of Heavy Prenatal Alcohol Exposure. J Int Neuropsychol Soc 24:1026-1037|
|Gross, Lauren A; Moore, Eileen M; Wozniak, Jeffrey R et al. (2018) Neural correlates of verbal memory in youth with heavy prenatal alcohol exposure. Brain Imaging Behav 12:806-822|
|Infante, M Alejandra; Moore, Eileen M; Bischoff-Grethe, Amanda et al. (2017) Altered functional connectivity during spatial working memory in children with heavy prenatal alcohol exposure. Alcohol 64:11-21|
|Glass, Leila; Moore, Eileen M; Akshoomoff, Natacha et al. (2017) Academic Difficulties in Children with Prenatal Alcohol Exposure: Presence, Profile, and Neural Correlates. Alcohol Clin Exp Res 41:1024-1034|
|Moore, Eileen M; Infante, M Alejandra; Migliorini, Robyn et al. (2016) Pituitary lacks sexual dimorphism and displays reduced signal intensity on T1-weighted MRI in adolescents with histories of heavy prenatal alcohol exposure. Neurotoxicol Teratol 57:106-111|
|Infante, M Alejandra; Moore, Eileen M; Nguyen, Tanya T et al. (2015) Objective assessment of ADHD core symptoms in children with heavy prenatal alcohol exposure. Physiol Behav 148:45-50|
|Moore, Eileen M; Riley, Edward P (2015) What Happens When Children with Fetal Alcohol Spectrum Disorders Become Adults? Curr Dev Disord Rep 2:219-227|
|Murawski, Nathen J; Moore, Eileen M; Thomas, Jennifer D et al. (2015) Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies. Alcohol Res 37:97-108|
|Migliorini, Robyn; Moore, Eileen M; Glass, Leila et al. (2015) Anterior cingulate cortex surface area relates to behavioral inhibition in adolescents with and without heavy prenatal alcohol exposure. Behav Brain Res 292:26-35|
|Infante, M Alejandra; Moore, Eileen M; Bischoff-Grethe, Amanda et al. (2015) Atypical cortical gyrification in adolescents with histories of heavy prenatal alcohol exposure. Brain Res 1624:446-454|