Abstract

Public Health Relevance

The adult mammalian intestine is one of the first sites of nutrient sensing and is maintained and regenerated by intestinal stem cells (ISCs). Age-associated decline of intestinal stem cells may impair renewal of the intestinal epithelium and predispose the elderly population to infections, digestive disorders and malabsorption. The work in this proposal aims to understand what role nutrient sensing pathways have on intestinal regeneration and whether pharmacological or dietary interventions have therapeutic applications for intestinal homeostasis in the aging population.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Career Transition Award (K99)
Project #
1K99AG054760-01A1
Application #
9385401
Study Section
Neuroscience of Aging Review Committee (NIA)
Program Officer
Macchiarini, Francesca
Project Start
2017-08-01
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Whitehead Institute for Biomedical Research
Department
Type
DUNS #
120989983
City
Cambridge
State
MA
Country
United States
Zip Code
02142

  Publications

Mihaylova, Maria M; Cheng, Chia-Wei; Cao, Amanda Q et al. (2018) Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell 22:769-778.e4