The goal of this K99/R00 application is to understand how mindfulness training may impact biobehavioral factors implicated in increased risk of cardiovascular disease (CVD). These factors include sleep (quality and quantity), psychological distress, and stress reactivity, including markers of inflammation. The candidate's training plan includes focused, mentored training in the areas of (a) sleep and its relation to CVD risk and pathophysiological mechanisms;(b) clinical trials methodology;and (c) structural linear modeling to guide translation of experimental data into novel interventions for CVD risk reduction. The K99 research project proposes to model individual differences in mindfulness-based stress reduction (MBSR) treatment outcomes, with a focus on examining intervention-related changes in mindfulness as a predictor of self-reported changes in cognitive and emotional functioning and sleep quality and duration. In addition, the K99 phase includes mentorship in statistical modeling of mechanisms linking psychological distress, sleep disturbance, inflammation and increased CVD risk. The R00 research project proposes a study of 50 men and women to test the hypothesis that MBSR-related increases in mindfulness predict improvements in sleep quality and quantity and decreases in physiological responses to an acute laboratory stressor, including inflammation. It is further hypothesized that improvements in sleep quality and quantity and attenuated stress physiology will be mediated, in part, by adaptive changes in cognitive and emotional processes, including less perseveration and increased emotion regulation. Finally, we hypothesize a bidirectional relationship between improved sleep and attenuated stress physiology following MBSR training. Modeling analyses will be translated into the development of an innovative brief intervention aimed at reducing biobehavioral risk for CVD by improving sleep quality, ameliorating psychological distress, and attenuating stress reactivity. This translational research program will extend existing knowledge by innovatively integrating work in psychology, complementary and alternative medicine (CAM), sleep, psychophysiology, immunology and CVD. This award will establish the candidate's career in the study of mindfulness as a mechanism of mind-body health and CVD risk reduction.

Public Health Relevance

This project aims to reduce CVD risk by informing novel treatment approaches to poor sleep quality and excessive stress reactivity, two factors associated with increased risk of CVD.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Career Transition Award (K99)
Project #
5K99AT004945-02
Application #
7692959
Study Section
Special Emphasis Panel (ZAT1-LD (25))
Program Officer
Glowa, John R
Project Start
2008-09-30
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
2
Fiscal Year
2009
Total Cost
$88,912
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Greeson, Jeffrey M; Zarrin, Haley; Smoski, Moria J et al. (2018) Mindfulness Meditation Targets Transdiagnostic Symptoms Implicated in Stress-Related Disorders: Understanding Relationships between Changes in Mindfulness, Sleep Quality, and Physical Symptoms. Evid Based Complement Alternat Med 2018:4505191
Greeson, Jeffrey M; Smoski, Moria J; Suarez, Edward C et al. (2015) Decreased symptoms of depression after mindfulness-based stress reduction: potential moderating effects of religiosity, spirituality, trait mindfulness, sex, and age. J Altern Complement Med 21:166-74
Caldwell, Karen; Emery, Lisa; Harrison, Mandy et al. (2011) Changes in mindfulness, well-being, and sleep quality in college students through taijiquan courses: a cohort control study. J Altern Complement Med 17:931-8
Wolever, Ruth Q; Webber, Daniel M; Meunier, Justin P et al. (2011) Modifiable disease risk, readiness to change, and psychosocial functioning improve with integrative medicine immersion model. Altern Ther Health Med 17:38-47
Feldman, Greg; Greeson, Jeff; Renna, Megan et al. (2011) Mindfulness predicts less texting while driving among young adults: Examining attention- and emotion-regulation motives as potential mediators. Pers Individ Dif 51:856-861
Greeson, Jeffrey M; Webber, Daniel M; Smoski, Moria J et al. (2011) Changes in spirituality partly explain health-related quality of life outcomes after Mindfulness-Based Stress Reduction. J Behav Med 34:508-18
Feldman, Greg; Greeson, Jeff; Senville, Joanna (2010) Differential effects of mindful breathing, progressive muscle relaxation, and loving-kindness meditation on decentering and negative reactions to repetitive thoughts. Behav Res Ther 48:1002-11
Caldwell, Karen; Harrison, Mandy; Adams, Marianne et al. (2010) Developing mindfulness in college students through movement-based courses: effects on self-regulatory self-efficacy, mood, stress, and sleep quality. J Am Coll Health 58:433-42
Greeson, Jeffrey M (2009) Mindfulness Research Update: 2008. Complement Health Pract Rev 14:10-18