? ? Dr. Gregory Wellenius's long-term career goal is to be become an independent investigator capable of leading patient-oriented research efforts in environmental cardiology. During the mentored (K99) phase of this career development award, the candidate will gain expertise in conducting patient-oriented mechanistic research in the setting of the General Clinical Research Center, assessment of vascular endothelial function, statistical methodology, and exposure assessment. The candidate will also establish his own laboratory, collect preliminary data, and refine power calculations during this phase. ? ? Dr. Murray Mittleman, the candidate's current post-doctoral mentor, will serve as primary mentor and oversee all aspects of the candidate's training. In addition, a team of three co-mentors with complimentary areas of expertise will supplement Dr. Wellenius's training in specific areas. Together, the mentor and co-mentors are committed to assisting the candidate reach his research training and career development goals and to ensuring the candidate's successful transition from postdoctoral fellow to independent researcher. ? ? During the independent (R00) phase of this award, the candidate will conduct a prospective, repeated-measures study to evaluate the mechanisms by which particulate air pollution affects autonomic function, inflammation, and vascular endothelial function in a cohort of patients with congestive heart failure. These putative mechanisms have been evaluated in a number of normal and susceptible populations, but never specifically in subjects with congestive heart failure. ? ? Relevance: Hospitalization rates among patients with congestive heart failure are extremely high. Epidemiologic studies suggest that short-term increases in ambient air pollution are associated with increased risk of hospitalization in this population, but the mechanisms of this effect have not been investigated. Understanding the underlying mechanisms may lead to new preventative strategies, new treatments, or improved air quality. ? ? ? ?
| Gronlund, Carina J; Zanobetti, Antonella; Wellenius, Gregory A et al. (2016) Vulnerability to Renal, Heat and Respiratory Hospitalizations During Extreme Heat Among U.S. Elderly. Clim Change 136:631-645 |
| Gronlund, Carina J; Zanobetti, Antonella; Schwartz, Joel D et al. (2014) Heat, heat waves, and hospital admissions among the elderly in the United States, 1992-2006. Environ Health Perspect 122:1187-92 |
| Wang, Yi; Eliot, Melissa N; Koutrakis, Petros et al. (2014) Ambient air pollution and depressive symptoms in older adults: results from the MOBILIZE Boston study. Environ Health Perspect 122:553-8 |
| Wang, Yi; Eliot, Melissa N; Kuchel, George A et al. (2014) Long-term exposure to ambient air pollution and serum leptin in older adults: results from the MOBILIZE Boston study. J Occup Environ Med 56:e73-7 |
| Wellenius, Gregory A; Boyle, Luke D; Wilker, Elissa H et al. (2013) Ambient fine particulate matter alters cerebral hemodynamics in the elderly. Stroke 44:1532-6 |
| Wilker, Elissa H; Yeh, Gloria; Wellenius, Gregory A et al. (2012) Ambient temperature and biomarkers of heart failure: a repeated measures analysis. Environ Health Perspect 120:1083-7 |
| Wellenius, Gregory A; Boyle, Luke D; Coull, Brent A et al. (2012) Residential proximity to nearest major roadway and cognitive function in community-dwelling seniors: results from the MOBILIZE Boston Study. J Am Geriatr Soc 60:2075-80 |
| Wellenius, Gregory A; Burger, Mary R; Coull, Brent A et al. (2012) Ambient air pollution and the risk of acute ischemic stroke. Arch Intern Med 172:229-34 |
| Wang, Shirley V; Coull, Brent A; Schwartz, Joel et al. (2011) Potential for bias in case-crossover studies with shared exposures analyzed using SAS. Am J Epidemiol 174:118-24 |
| Wang, Shirley; Linkletter, Crystal; Maclure, Malcolm et al. (2011) Future cases as present controls to adjust for exposure trend bias in case-only studies. Epidemiology 22:568-74 |
Showing the most recent 10 out of 18 publications
