The mammalian brain builds and transforms representations of the outside world through the concerted activity of populations of neurons, but the extent to which spike times or spike counts are coordinated within these ensembles beyond pairs is not clear. Models of neural encoding predict variable frequencies of spike pattern occurrence, and models of decoding delineate requirements for spike time precision within the population response. While considerable effort has been made toward the development and refinement of the theoretical basis of such neural coding schemes, and predictions have been tested against single cell and pairwise data, there has been relatively little experimental data beyond pairs able to differentiate between competing hypotheses of population coding. The proposed career development plan aims to marry large-scale electrophysiology in primary visual cortex with analysis of specific predictions derived from computational and theoretical neuroscience work for spike time coordination beyond pairwise interactions. The candidate has a deep background in in vivo experimental techniques and proposes to receive training in the high-dimensional computational techniques and to use experimental data collected to validate specific theoretical predictions. This training will establish the skills necessary for a successful independent research career studying the mechanisms of information representation and transfer in visual cortex, bridging the gap between experimental and computational neuroscience. The candidate will carry out the mentored phase under the guidance of Dr. Clay Reid, a world expert in multiple aspects of mammalian central visual processing including anatomy, physiology, and computation. Additional advising from Dr. Eric Shea- Brown and Dr. Christof Koch will provide guidance in the theoretical and applied mathematical approaches required to implement and assess advanced models of neural encoding and decoding. The training will utilize the strengths of the Allen Institute for Brain Science in collecting large-scale data and the didactic opportunities at the University of Washington. In the independent phase the candidate will use the newly acquired analytical and modeling skills in combination with his previous training in optogenetic techniques to better constrain population measurements. This work will help establish a unique independent research program to elucidate the mechanisms underlying cortical representation.

Public Health Relevance

Understanding how the brain uses population activity to build representations of the outside world is an important step towards understanding not only sensory but also psychiatric and other cognitive disorders. This work on the fundamental nature of the neural code will contribute to the body of knowledge required to create effective brain interfaces for motor and sensory prostheses with the potential to reduce sensory disabilities, provide treatments for cognitive disorders, and aid in recovery from central nervous system trauma.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Career Transition Award (K99)
Project #
5K99EY028612-02
Application #
9752555
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Agarwal, Neeraj
Project Start
2018-08-05
Project End
2019-08-28
Budget Start
2019-08-01
Budget End
2019-08-28
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Allen Institute
Department
Type
DUNS #
137210949
City
Seattle
State
WA
Country
United States
Zip Code
98109