Why have there.not been more successes in translating exciting scientific discoveries into improved patient care and community health (1,2)? Possible explanations include a shortage and high turnover rate of clinicianinvestigators due to insufficient institutional and environmental support (3); reluctance to let go of the traditional department-centric research and training models; a lack of effectiveness in educating PhD scientists about the physiology and pathophysiology of human health and disease (4); and a gap in providing clinical and bench scientists with the tools needed to be successful in the current research environment, including working in interdisciplinary teams. In this section we propose solutions to these possible barriers and provide an implementation plan that is achievable and can be evaluated. ? The overall goal of this key component of our CTSA application is to create the next generation of clinical researchers representing multiple disciplines who will be boundary spanners, able to pollinate new ideas and link laboratories and investigators in different disciplines. Northwestern University has fostered interdisciplinary research for several decades. It has provided incentives Including faculty positions and research funding to break the lines and barriers separating disciplines, and merged discipline-based graduate training programs in the life sciences and engineering into 4 integrated programs that span campus locations. We propose building on an already successful program of interdisciplinary research education, training and career development by establishing the Center for Clinical Research Education (CCRE). The Center will coordinate and enhance existing clinical and translational research education, training and career development activities; create new courses, seminars and programs and integrate them with existing activities; expand the candidate pool for our programs by including predoctoral trainees and basic scientists; educate/train the candidates differently than in the past using an expanded set of course offerings and seminars and established interdisciplinary, teams, and nurture the trainees using carefully chosen mentors and new oversight procedures including standardized tracking tools. The Center will also provide new opportunities for clinical research and regulatory staff and community investigators. The Center and its key programs will be led by a dynamic and experienced leadership team.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Mentored Career Development Award (KL2)
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Study Section
Special Emphasis Panel (ZRR1-SRC (99))
Program Officer
Mccloskey, Donna J
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Northwestern University at Chicago
Public Health & Prev Medicine
Schools of Medicine
United States
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D'Anna, Lucio; Mesulam, Marsel M; Thiebaut de Schotten, Michel et al. (2016) Frontotemporal networks and behavioral symptoms in primary progressive aphasia. Neurology 86:1393-1399
O'leary, Shaun; Jull, Gwendolen; Van Wyk, Luke et al. (2015) Morphological changes in the cervical muscles of women with chronic whiplash can be modified with exercise-A pilot study. Muscle Nerve 52:772-9
Baldridge, Abigail S; Pacheco, Jennifer A; Aufox, Sharon A et al. (2015) Factors Associated With Long-Term Weight Loss Following Bariatric Surgery Using 2 Methods for Repeated Measures Analysis. Am J Epidemiol 182:235-43
Elliott, James M; Courtney, D Mark; Rademaker, Alfred et al. (2015) The Rapid and Progressive Degeneration of the Cervical Multifidus in Whiplash: An MRI Study of Fatty Infiltration. Spine (Phila Pa 1976) 40:E694-700
Rasmussen-Torvik, Laura J; Baldridge, Abigail S; Pacheco, Jennifer A et al. (2015) rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery. Obes Surg 25:2225-9
Smith, Andrew C; Parrish, Todd B; Abbott, Rebecca et al. (2014) Muscle-fat MRI: 1.5 Tesla and 3.0 Tesla versus histology. Muscle Nerve 50:170-6
Salsman, John M; Lai, Jin-Shei; Hendrie, Hugh C et al. (2014) Assessing psychological well-being: self-report instruments for the NIH Toolbox. Qual Life Res 23:205-15
Pang, Peter S; Collins, Sean P; Sauser, Kori et al. (2014) Assessment of dyspnea early in acute heart failure: patient characteristics and response differences between likert and visual analog scales. Acad Emerg Med 21:659-66
Elliott, James M; Dewald, Julius P A; Hornby, T George et al. (2014) Mechanisms underlying chronic whiplash: contributions from an incomplete spinal cord injury? Pain Med 15:1938-44
Rogalski, Emily; Weintraub, Sandra; Mesulam, M-Marsel (2013) Are there susceptibility factors for primary progressive aphasia? Brain Lang 127:135-8

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