Virginia Commonwealth University (VCU) seeks funding for an Institutional Clinical and Translational Science Awiard (CTSA). This opportunity comes at a pivotal phase in VCU's growth and development as a premier biomedical research institution and coincides with significant institutional commitment and direction recommended by the Board of Visitors. To accomplish the goals of the CTSA initiative, VCU has establisheda comprehensive matrix center, the Center for Clinical and Translational Research (CCTR). The CCTR willfacilitate the development of new pailnerships and new initiatives that will extend our research base of fed-eral, private, and industry sponsored awards. Our already strong research program will be encouraged andabetted by a cultural transformation to support translational science and an influx of newly recruited multi-disciplinary investigators. The CCTR leverages substantial existing resources to encourage and supportnovel research methodologies at VCU. Emphasis is placed on three areas of research strength; namelysubstance abuse, women's health and rehabilitation science. Pilot funds will be awarded to support innova-tion and community engagement research in these areas. Architecture for a Clinical and Translational DataEnvironment, an enterprise data warehouse, and a collaborative web portal to facilitate data sharing acrossVCU, VCU Health System (VCUHS), other CTSA sites and national research networks has been developedA Research Incubator provides biostatistical support, facilitates research, encourages research in researchethics and provides guidance in regulatory issues. Strategies to enhance research subject participation,facilities for the conduction of human research, and access to the IVIid-Atlantic Twin Registry are described.Centralized management of and access to a rich array of research resources will be accomplished throughthe CCTR. Our students will enroll in trans-disciplinary educational cumcula which encourage team buildingincluding both a MS and a PhD in Clinical and Translational Science. CCTR will strengthen ties with ouraffiliates and community partners to make better use of their unique resources and respond to their needs.

Public Health Relevance

Effective delivery of research which moves from the bench to the bedside to the community requires atransformation of research practice at every level. The present grant will support the efforts of VCU tostrengthen ties with our affiliates and community partners to make better use of their unique resources andrespond to their needs.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Mentored Career Development Award (KL2)
Project #
1KL2RR031989-01
Application #
8066143
Study Section
Special Emphasis Panel (ZRR1-CR-1 (02))
Program Officer
Rosenblum, Daniel
Project Start
2010-07-01
Project End
2015-03-31
Budget Start
2010-07-01
Budget End
2011-03-31
Support Year
1
Fiscal Year
2010
Total Cost
$497,500
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Dusing, Stacey C; Thacker, Leroy R; Galloway, James C (2016) Infant born preterm have delayed development of adaptive postural control in the first 5 months of life. Infant Behav Dev 44:49-58
Abbate, Antonio; Kontos, Michael Christopher; Abouzaki, Nayef Antar et al. (2015) Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies). Am J Cardiol 115:288-92
Coe, Antoinette B; Moczygemba, Leticia R; Gatewood, Sharon B S et al. (2015) Medication adherence challenges among patients experiencing homelessness in a behavioral health clinic. Res Social Adm Pharm 11:e110-20
Falcao, Raquel Appa; Christopher, Sanah; Oddi, Claudia et al. (2014) Interleukin-10 in patients with ST-segment elevation myocardial infarction. Int J Cardiol 172:e6-8
Evangelou, Iordanis E; Massoud, Raya; Jacobson, Steven (2014) HTLV-I-associated myelopathy/tropical spastic paraparesis: semiautomatic quantification of spinal cord atrophy from 3-dimensional MR images. J Neuroimaging 24:74-8
Van Tassell, Benjamin Wallace; Arena, Ross; Biondi-Zoccai, Giuseppe et al. (2014) Effects of interleukin-1 blockade with anakinra on aerobic exercise capacity in patients with heart failure and preserved ejection fraction (from the D-HART pilot study). Am J Cardiol 113:321-327
Vecile, Elena; Dobrina, Aldo; Salloum, Fadi N et al. (2013) Intracellular function of interleukin-1 receptor antagonist in ischemic cardiomyocytes. PLoS One 8:e53265
Abbate, Antonio; Van Tassell, Benjamin Wallace; Biondi-Zoccai, Giuseppe et al. (2013) Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]. Am J Cardiol 111:1394-400
Ohayon, Joan; Oh, Unsong; Richert, Nancy et al. (2013) CNS vasculitis in a patient with MS on daclizumab monotherapy. Neurology 80:453-7
Toldo, Stefano; Mezzaroma, Eleonora; Van Tassell, Benjamin W et al. (2013) Interleukin-1? blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse. Exp Physiol 98:734-45

Showing the most recent 10 out of 31 publications