Virginia Commonwealth University (VCU) seeks funding for an Institutional Clinical and Translational Science Awiard (CTSA). This opportunity comes at a pivotal phase in VCU's growth and development as a premier biomedical research institution and coincides with significant institutional commitment and direction recommended by the Board of Visitors. To accomplish the goals of the CTSA initiative, VCU has established a comprehensive matrix center, the Center for Clinical and Translational Research (CCTR). The CCTR will facilitate the development of new pailnerships and new initiatives that will extend our research base of fed- eral, private, and industry sponsored awards. Our already strong research program will be encouraged and abetted by a cultural transformation to support translational science and an influx of newly recruited multi- disciplinary investigators. The CCTR leverages substantial existing resources to encourage and support novel research methodologies at VCU. Emphasis is placed on three areas of research strength;namely substance abuse, women's health and rehabilitation science. Pilot funds will be awarded to support innova- tion and community engagement research in these areas. Architecture for a Clinical and Translational Data Environment, an enterprise data warehouse, and a collaborative web portal to facilitate data sharing across VCU, VCU Health System (VCUHS), other CTSA sites and national research networks has been developed A Research Incubator provides biostatistical support, facilitates research, encourages research in research ethics and provides guidance in regulatory issues. Strategies to enhance research subject participation, facilities for the conduction of human research, and access to the IVIid-Atlantic Twin Registry are described. Centralized management of and access to a rich array of research resources will be accomplished through the CCTR. Our students will enroll in trans-disciplinary educational cumcula which encourage team building including both a MS and a PhD in Clinical and Translational Science. CCTR will strengthen ties with our affiliates and community partners to make better use of their unique resources and respond to their needs.

Public Health Relevance

Effective delivery of research which moves from the bench to the bedside to the community requires a transformation of research practice at every level. The present grant will support the efforts of VCU to strengthen ties with our affiliates and community partners to make better use of their unique resources and respond to their needs.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
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Special Emphasis Panel (ZRR1)
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Sufian, Meryl
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Virginia Commonwealth University
Internal Medicine/Medicine
Schools of Medicine
United States
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Edwards, Alexis C; Deak, Joseph D; Gizer, Ian R et al. (2018) Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity. Alcohol Clin Exp Res 42:2349-2359
Kimmel, April D; Masiano, Steven P; Bono, Rose S et al. (2018) Structural barriers to comprehensive, coordinated HIV care: geographic accessibility in the US South. AIDS Care 30:1459-1468
Darter, Benjamin J; Hawley, Carolyn E; Armstrong, Amy J et al. (2018) Factors Influencing Functional Outcomes and Return-to-Work After Amputation: A Review of the Literature. J Occup Rehabil 28:656-665
Darter, Benjamin J; Labrecque, Bethany A; Perera, Robert A (2018) Dynamic stability during split-belt walking and the relationship with step length symmetry. Gait Posture 62:86-91
DeLigio, James T; Lin, Grace; Chalfant, Charles E et al. (2017) Splice variants of cytosolic polyadenylation element-binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis. J Biol Chem 292:17909-17918
Crump, Katie E; Oakley, Jennifer C; Xia-Juan, Xia et al. (2017) Interplay of Toll-Like Receptor 9, Myeloid Cells, and Deubiquitinase A20 in Periodontal Inflammation. Infect Immun 85:
Mahon, Caitlin E; Pruziner, Alison L; Hendershot, Brad D et al. (2017) Gait and Functional Outcomes for Young, Active Males With Traumatic Unilateral Transfemoral Limb Loss. Mil Med 182:e1913-e1923
Gupta, Anshu; Uribarri, Jaime (2016) Dietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children. Horm Res Paediatr 85:291-300
Bowers, M S; Jackson, A; Maldoon, P P et al. (2016) N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice. Psychopharmacology (Berl) 233:995-1003
Goldberg-Looney, Lisa D; Perrin, Paul B; Snipes, Daniel J et al. (2016) Coping styles used by sexual minority men who experience intimate partner violence. J Clin Nurs 25:3687-3696

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