This is the second resubmission application for a Clinical and Translational Science Award. We describe Penn State University's plan to transform our health research and education enterprise through the work of the Penn State Clinical and Translational Science Institute (CTSI). Throughout the University, the CTSI initiative has been greeted with great enthusiasm, broad support across colleges and campuses, and reaffirmation of our responsibility as a land grant University. The overarching goal of the Penn State CTSI is an engaged and responsive health science research and education enterprise that delivers on the promise of improved health. Starting with unique strengths in relevant biological, social and physical sciences, a culture and organizational structure that encourages collaboration across units, a tradition of engaging in problem-driven research, and strong connections to communities throughout Pennsylvania, we plan to achieve this by: 1) bolstering community alliances to strengthen trust, enhance awareness of disparities and ascertain needs;2) cultivating new problem-driven interdisciplinary collaborations that go well beyond the traditional boundaries of biomedicine to address these needs, including partnering with industry;3) sharing resources and promoting their most proficient use;4) capitalizing on novel tools in information technology to collect, share and mine data, and disseminate new knowledge;and 5) educating a new generation of investigators, health professionals and community leaders who are fluent across disciplines, aware of ethical principles, sensitive to the community's needs, and able to apply their skills in partnership with others. Penn State has a rich track record of breaking down barriers and of strong support for interdisciplinary collaboration, and has committed major resources to the CTSI. In this amended application, a new leadership team in biomedical informatics has been empowered to expand infrastructure and develop new software solutions to study genetics, epigenetics and systems biology. The University has increased its already substantial health science investment in transformational technologies, innovative educational programs, and major interdisciplinary pilot project programs. Jointly with our community partners, and through the CTSA consortium, the Penn State CTSI will serve as a collaborative engine that will drive research initiatives geared to enhance wellness and better predict, preempt and treat disease in the people we serve.

Public Health Relevance

This proposal describes the newly created Penn State Clinical and Translational Science Institute (CTSI). The overarching goal of our CTSI initiative is to revitalize the health science research and education enterprise at our University to better enable it to deliver on the promise of improved health.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Program Officer
Wilson, Todd
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Pennsylvania State University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Li, Zheng; Chinchilli, Vernon M; Wang, Ming (2018) A Bayesian joint model of recurrent events and a terminal event. Biom J :
Hobkirk, Andréa L; Krebs, Nicolle M; Muscat, Joshua E (2018) Income as a moderator of psychological stress and nicotine dependence among adult smokers. Addict Behav 84:215-223
Wang, Ming; Matthews, Stephen A; Iskandarani, Khaled et al. (2017) Spatial-temporal analysis of prostate cancer incidence from the Pennsylvania Cancer Registry, 2000-2011. Geospat Health 12:611
Savage, Jennifer S; Rollins, Brandi Y; Kugler, Kari C et al. (2017) Development of a theory-based questionnaire to assess structure and control in parent feeding (SCPF). Int J Behav Nutr Phys Act 14:9
Babinski, Dara E; Neely, Kristina A; Kunselman, Allen et al. (2017) Attention-deficit/hyperactivity disorder and callous-unemotional traits as moderators of conduct problems when examining impairment in emerging adults. Psychiatry Res 258:525-530
Millett, Caitlin E; Mukherjee, Dahlia; Reider, Aubrey et al. (2017) Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner. Psychiatry Res 255:52-58
Jariwala, Shailly H; Wee, Hwabok; Roush, Evan P et al. (2017) Time course of peri-implant bone regeneration around loaded and unloaded implants in a rat model. J Orthop Res 35:997-1006
Bleser, William K; Young, Sara I; Miranda, Patricia Y (2017) Disparities in Patient- and Family-Centered Care During US Children's Health Care Encounters: A Closer Examination. Acad Pediatr 17:17-26
Muller, Matthew D; Ahmad, Tariq Ali; Vargas Pelaez, Alvaro F et al. (2017) Esmolol infusion versus propranolol infusion: effects on heart rate and blood pressure in healthy volunteers. J Appl Physiol (1985) 122:511-519
Wee, Hwabok; Reid, J Spence; Chinchilli, Vernon M et al. (2017) Finite Element-Derived Surrogate Models of Locked Plate Fracture Fixation Biomechanics. Ann Biomed Eng 45:668-680

Showing the most recent 10 out of 85 publications