The Clinical and Translational Science Collaborative (CTSC) of Cleveland is a collaborative venture among five Cleveland health institutions - Case Western Reserve University, the Cleveland Clinic, University Hospitals, MetroHealth Medical Center, and the Veterans Administration Medical Center, as well as community partners. CTSC achieved prior goals of uniting as a collaborative, developed informatics tools, resource sharing, and institutional commitments to enhance the collaborative. Consolidation and catalytic activities begun in the last grant period will be continued. Moreover, CTSC will continue rigorous evaluation of both its operations and progress toward larger goals. CTSC has set three new goals for the next grant period.' 1) Translation 1 research will be enhanced. Infrastructure in support of identification and structural determination of therapeutic targets, as well as high through put screening will be implemented. Support systems to assist in patient based research both recruitment and testing will be streamlined and strengthened. Critically, CTSC will create support systems to guide development of potential human therapeutics and diagnostics from discovery to use in man, 2) CTSC will improve health parameters in Cleveland, one of America's poorest and least healthy cities. Community Research Partnership Core is querying the community via neighborhood focus groups to determine their health priorities. At least one of these priorities, and others selected based on the strengths of our CTSC investigative community, will be targeted for special effort. One practice based research network has already succeeded in reducing HgbAlc in 27,000 diabetics in Cleveland by one percentage point in three years, raising optimism that this project can indeed move the needle. 3) CTSC interactions with the national CTSA community will increase. The initial focus of CTSC was inward, establishing connections and catalyzing change in our home institutions, but in the next grant period the CTSC will increase interactions around the consortium. A primary focus will be the Ohio Consortium of the three Ohio CTSAs (CTSC, Columbus, Cincinnati), which currently collaborate surrounding child health and cancer projects, and on the web site NetWellness, which has been expanded from simply providing unbiased medical information to include descriptions of clinical research and access to clinical trials. In the next grant period goals will include extending the CTSC IRB electronic hub for facilitated review to include the other CTSA sites, increasing project collaboration, and connecting patient databases via Explorys, a web based informatics tool utilizing the electronic health record.

Public Health Relevance

The CTSC is highly relevant to human health. Using the Cleveland biomedical community as a prototype, we will develop and test electronic and other strategies for coordinating research functions among different institutions, such as IRB approval and facile data sharing. Using the Cleveland community as a laboratory and our practice based research networks and community partnership resource as tools, we will seek to improve health parameters in Cleveland. We will also develop more facile means for Translation 1.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR000440-09
Application #
8891230
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Davis Nagel, Joan
Project Start
2007-09-17
Project End
2017-05-31
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
9
Fiscal Year
2015
Total Cost
$2,228,126
Indirect Cost
$161,168
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Wright, Kathy D; Still, Carolyn H; Jones, Lenette M et al. (2018) Designing a Cocreated Intervention with African American Older Adults for Hypertension Self-Management. Int J Hypertens 2018:7591289
Chen, Yong; Lo, Wei-Ching; Hamilton, Jesse I et al. (2018) Single breath-hold 3D cardiac T1 mapping using through-time spiral GRAPPA. NMR Biomed 31:e3923
Chao, Cecilia; Akileswaran, Lakshmi; Cooke Bailey, Jessica N et al. (2018) Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers. Invest Ophthalmol Vis Sci 59:5752-5761
Bruno, Bethany; Arora, Kavita Shah (2018) Uterus Transplantation: Response to Open Peer Commentaries on the Ethics of Using Deceased Versus Living Donors. Am J Bioeth 18:W6-W8
Montague, Mary; Ascha, Mustafa; Wilkinson, Barbara et al. (2018) Role of Bridge Contraception in Postpartum Long-Acting Reversible Contraception and Sterilization Fulfillment Rates. Obstet Gynecol 132:583-590
Taksler, Glen B; Keating, Nancy L; Rothberg, Michael B (2018) Implications of false-positive results for future cancer screenings. Cancer 124:2390-2398
Taksler, Glen B; Pfoh, Elizabeth R; Stange, Kurt C et al. (2018) Association Between Number of Preventive Care Guidelines and Preventive Care Utilization by Patients. Am J Prev Med 55:1-10
Aftab, Awais; Bhat, Chetan; Gunzler, Douglas et al. (2018) Associations among comorbid anxiety, psychiatric symptomatology, and diabetic control in a population with serious mental illness and diabetes: Findings from an interventional randomized controlled trial. Int J Psychiatry Med 53:126-140
Ho, Vanessa P; Steinhagen, Emily; Angell, Kelsey et al. (2018) Psychiatric disease in surgically treated colorectal cancer patients. J Surg Res 223:8-15
Still, Carolyn Harmon; Jones, Lenette M; Moss, Karen O et al. (2018) African American Older Adults' Perceived Use of Technology for Hypertension Self-Management. Res Gerontol Nurs 11:249-256

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