One of medicine's greatest challenges today is the efficient, seamless and safe translation of biomedicalresearch discoveries into clinical applications that improve human health. New methodologies, technologiesand integrated information systems offer unprecedented promise for discovery and growth of translationalsuccesses; however significant barriers continue to confound our ability to rapidly move discoveries intoclinical practice, including the efficiency, cost and effectiveness of our research processes. The ColoradoClinical and Translational Sciences Institute (CCTSl), created in 2008, has addressed these challenges andtransformed our institutional research infrastructure. In this application, the University of Colorado Denver(CU-D) and our partner institutions (CU-Boulder and Colorado State University [CSU], six major hospitalsand health care organizations and local communities) will re-engineer the CCTSl through the following fiveStrategic Goals: 1) Enrich and expand our integrated statewide academic home for clinicaland translationalresearch. 2) Institute new clinical research management strategies to strengthen quality, safety, efficiency,cost effectiveness and innovative team science, including implementing new software systems and workflows. 3) Centralize and enhance the delivery of our outstanding resources, services and technologies andinstitute charge-backs to investigators where appropriate. 4) Infuse key concepts of community engagementinto the full spectrum of translational research. 5) Increase the translational research workforce capacitythrough a broad curriculum of education, training and career development opportunities. A rigorous tracking,assessment and evaluation program coupled to a formal quality and process improvement programembedded in the CCCTSl will ensure the most efficient, cost-effective, and innovative use of our preciousresources, while protecting the safety of our study participants. These programs will be centralized at one ofthe newest biomedical research, education and clinical enterprises in the nation, the CU Anschutz MedicalCampus in which adjacencies of our schools, research laboratories, three hospitals and a biomedicalcorporate park create the ideal environment for our success.

Public Health Relevance

The relevance of this project to public health lies in our ability to help researchers take important discoveriesand translate them into new treatments, preventions and cures for human diseases. We also will helpresearchers find ways to bring these therapies into the community setting to benefit people across our stateand country.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
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Special Emphasis Panel (ZAI1-PTM-C (S2))
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Purucker, Mary E
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University of Colorado Denver
Schools of Medicine
United States
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