The incongruence between advances in basic and computational discovery, and the continuing unmet health needs of the population, demands a radical acceleration of clinical and translational science. While health concerns affect all social strata, disease impact is greatest on the poor and marginalized, particularly in ethnic and racial minority communities. In confronting this critical need, the major remediable gap is the paucity of interdisciplinary investigators to rapidly translate new knowledge from bench to bedside to community. We propose a full-time KL2 Mentored Career Development program to advance the translational careers of innovative clinically oriented post-doctoral scientists from diverse research backgrounds and perspectives (T1- T4). The KL2 aims to provide trainees with the knowledge and skills to conduct pioneering and effective clinical and translational science in an ethically responsible manner. There are six key activities by which we seek to meet our overarching objective. 1) An Individualized Development Plan, entailing a comprehensive assessment of KL2 Scholars? strengths and areas for improvement. 2) Scholar-specific mentoring committees that meet biannually to track and support career trajectories. 3) Monthly group meetings with the KL2 directors. 4) Formal didactic instruction. 5) Support for innovative and specialized training environments and settings. 6) Protected time for conducting a mentored research program and undergoing individualized training. KL2 Scholars will successfully complete training on the responsible conduct of research, general and targeted formal didactics, Masters-level training in multidisciplinary translational programs, specialized/advanced course work, training in team science, individualized training in grant preparation, exposure to alternative career opportunities, distance and exchange training, and mentored performance of an innovative high-impact translational research project. Target expectations include publication of ?2 manuscripts and submission of a K-level grant or equivalent. We will recruit sequential cohorts of three Scholars each, all with doctoral degrees (MD, PhD, DDS, PsyD, etc.) and extensive prior research training (?2 years post-doctorate), for a 2-year cycle of training (total=9). Scholars will dedicate ?75% effort to career development activities, supported by KL2 directors with extensive and exemplary mentoring experience, a strongly invested KL2 Executive Committee, and a broad and diverse Program Faculty who will serve on Scholar-specific mentoring committees to assure continuation of our excellent prior experience in the initial iteration of the KL2 program.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
1KL2TR001446-01
Application #
9085752
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Talbot, Bernard
Project Start
2015-08-18
Project End
2020-03-31
Budget Start
2015-08-18
Budget End
2016-03-31
Support Year
1
Fiscal Year
2015
Total Cost
$488,725
Indirect Cost
$35,325
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Han, Benjamin H; Moore, Alison A (2018) Prevention and Screening of Unhealthy Substance Use by Older Adults. Clin Geriatr Med 34:117-129
Kwon, Simona C; Han, Benjamin H; Kranick, Julie A et al. (2018) Racial and Ethnic Difference in Falls Among Older Adults: Results from the California Health Interview Survey. J Racial Ethn Health Disparities 5:271-278
Han, Benjamin H; Moore, Alison A; Sherman, Scott E et al. (2018) Prevalence and correlates of binge drinking among older adults with multimorbidity. Drug Alcohol Depend 187:48-54
Han, Benjamin H; Masukawa, Kristin; Rosenbloom, David et al. (2018) Use of web-based screening and brief intervention for unhealthy alcohol use by older adults. J Subst Abuse Treat 86:70-77
Neogi, Tuhina; Krasnokutsky, Svetlana; Pillinger, Michael H (2018) Urate and osteoarthritis: Evidence for a reciprocal relationship. Joint Bone Spine :
Heffron, Sean P; Lin, Bing-Xue; Parikh, Manish et al. (2018) Changes in High-Density Lipoprotein Cholesterol Efflux Capacity After Bariatric Surgery Are Procedure Dependent. Arterioscler Thromb Vasc Biol 38:245-254
Rivera-Correa, J; Guthmiller, J J; Vijay, R et al. (2017) Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria. Nat Commun 8:1282
Heffron, Sean P; Rockman, Caron B; Adelman, Mark A et al. (2017) Greater Frequency of Fruit and Vegetable Consumption Is Associated With Lower Prevalence of Peripheral Artery Disease. Arterioscler Thromb Vasc Biol 37:1234-1240
Han, Benjamin H; Moore, Alison A; Sherman, Scott et al. (2017) Demographic trends of binge alcohol use and alcohol use disorders among older adults in the United States, 2005-2014. Drug Alcohol Depend 170:198-207
Han, Benjamin H; Sherman, Scott E; Link, Alissa R et al. (2017) Comparison of the Substance Use Brief Screen (SUBS) to the AUDIT-C and ASSIST for detecting unhealthy alcohol and drug use in a population of hospitalized smokers. J Subst Abuse Treat 79:67-74

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