Contact PD/PI: Guay-Woodford, Lisa Marie Inst-Career-Dev-001 (495) Project Summary Abstract We propose a Mentored Career Development Plan that will utilize the resources of CTSI-CN v2.0 and our partner institutions, Children's National Health System, the George Washington University and Virginia Tech/Carilion Clinic. The focus of the KL2 program is on childhood disorders as precursors of adult disease. We propose an approach with team mentorship, multi-institutional courses and access to a large research skills development toolbox. It will also provide a strong portfolio of biomedical, health services, pharma, industry, and not-for-profit externships. Our research education paradigm utilizes blended learning that includes distance education and an online learning portal. Through the resources of the CTSA Scholarly Oversight Committee and the Grants Enhancement Program, the KL2 scholar will master CTR core competencies and be well prepared in all aspects of developing and submitting competitive NIH grant applications by the end of their training period. Of high priority is promoting diversity among recruited scholars and mentors, with specific strategies proposed for recruitment, retention and individualized supports. The KL2 scholar will: 1) complete graduate level courses in CTR, bioinformatics, systems biology, and health policy relevant to their area of research; 2) learn state-of-the-art laboratory, statistical, and epidemiological methodologies; 3) collect and analyze preliminary data with guidance from a Lead Mentor and Mentorship Team; 4) prepare and submit an NIH grant application; and 5) become versed in various strategies to translate their scientific findings into the next stages of clinical applications. Our proposed program ensures scholars will have 75% protected time. We draw on 48 mentors/co-mentors in affinity areas that include genomics/proteinomic with clinical phenotyping; chemical/biological/cellular therapies; biomedical imaging and engineering; rigorous clinical trials; and health disparities/health services research. Our scholars will participate in CTSA-network activities including a distance externship program initiated by the Medical University of South Carolina CTSA; our novel R25 curriculum entitled ?Innovations in Pediatric CTR Education?; a planned R13- supported satellite conference for pediatric-focused KL2s at the annual Association for Clinical and Translation Science meeting, and a multidisciplinary consortium pilot program proposed in the CTSI-CN U54-application, the ?Child Health Research Acceleration through Multisite Planning (CHAMP)?. The administrative structure of the KL2 includes a Project Lead and three Project Co-Leads with complementary skill sets in clinical research, team science/leadership, and educational design. We propose to select and train 9 scholars over the grant period, 4 with federal and 5 with institutional funding. We will use ongoing evaluation methods to continuously strengthen and refine out training program and measure its long-term impact on scientific careers and research contributions in CTR. Project Summary/Abstract Page 356 Contact PD/PI: Guay-Woodford, Lisa Marie Inst-Career-Dev-001 (495) REFERENCES DeCastro R, Sambuco D, Ubel PA, Stewart A, Jagsi R. Mentor networks in academic medicine: moving beyond a dyadic conception of mentoring for junior faculty researchers. Acad Med. 2013 Apr;88(4):488-96. PMID: 23425990 Graham, C. R. (2005). Blended learning systems: Definition, current trends, and future directions. In C. J. Bonk & C. R. Graham, (Eds.), Handbook of blended learning: Global perspectives, local designs. San Francisco, CA: Pfeiffer Publishing. Lee, LS, Pusek, SN, McCormack, WT, Helitzer, DL, Martina, CA, Dozier, AM, Ahluwalia, JS, Schwartz, LS, McManus, LM, Reynolds, BD, Haynes, EN, Rubio, DM: Clinical and translational scientist career success: metrics for evaluation. Clinical and Translational science, 5: 400-407, 2012. Lee LS, Pusek SN, McCormack WT, et al. Clinical and translational scientist career success: metrics for evaluation. Clin Transl Sci. 2012 Oct;5(5):400-7. PMID:23067352 Matthews KR, Calhoun KM, Lo N, Ho V. The aging of biomedical research in the United States. PLoS One. 2011;6(12):e29738. PMID: 22216352 Rivkees SA. The Missing Link of NIH Funding in Pediatric Research Training Program Restructuring. Pediatrics. 2014 Dec;134(6):e1521-2. PMID: 25367541 Robinson, GFWB, Schwartz, LS, DiMeglio, LA, Ahluwalia, JS, Gabrilove, JL. Understanding career success and contributing factors for clinical and translational investigators. Submitted to Academic Medicine in September 2014 (under review) Robinson GFWB, Schwartz LS, DiMeglio LA, Ahuluwalia JS, et al. Understanding career success and contributing factors for clinical and translational investigators. Academic Medicine. Submitted September 2014 (under review) Rohlfing J, Navarro R, Maniya OZ, Hughes BD, Rogalsky DK. Medical student debt and major life choices other than specialty. Med Educ Online. 2014 Nov 11;19:25603. PMID:25391976 Winer KK, Rothenberg ME, Guimond J, et al. The Child Health Research Centers: twenty-one years of promoting the development of pediatrician scientist from 1990-2011. J Pediatr 2012. 161:975. PMID 23171484 References Cited Page 357
| Ho, Cheng-Ying; Castillo, Nicolas; Encinales, Liliana et al. (2018) Second-trimester Ultrasound and Neuropathologic Findings in Congenital Zika Virus Infection. Pediatr Infect Dis J 37:1290-1293 |
| Chang, Aileen Y; Lynch, Rebecca; Martins, Karen et al. (2018) Long-term clinical outcomes of Zika-associated Guillain-Barré syndrome. Emerg Microbes Infect 7:148 |
| Pérez-Losada, Marcos; Graham, Robert J; Coquillette, Madeline et al. (2018) Tracheal Microbiota in Patients With a Tracheostomy Before, During and After an Acute Respiratory Infection. Pediatr Infect Dis J 37:e269-e271 |
| Hahn, Andrea; Warnken, Stephanie; Pérez-Losada, Marcos et al. (2018) Microbial diversity within the airway microbiome in chronic pediatric lung diseases. Infect Genet Evol 63:316-325 |
| Chang, Aileen Y; Bethony, Jeffrey M; Simon, Gary L et al. (2018) Reply. Arthritis Rheumatol 70:1166-1167 |
| Mulkey, Sarah B; du Plessis, Adre J (2018) Autonomic nervous system development and its impact on neuropsychiatric outcome. Pediatr Res : |
| Mulkey, Sarah B; Kota, Srinivas; Swisher, Christopher B et al. (2018) Autonomic nervous system depression at term in neurologically normal premature infants. Early Hum Dev 123:11-16 |
| Roche, Kathleen M; Vaquera, Elizabeth; White, Rebecca M B et al. (2018) Impacts of Immigration Actions and News and the Psychological Distress of U.S. Latino Parents Raising Adolescents. J Adolesc Health 62:525-531 |
| Perez, Geovanny F; Pérez-Losada, Marcos; Isaza, Natalia et al. (2017) Nasopharyngeal microbiome in premature infants and stability during rhinovirus infection. J Investig Med 65:984-990 |
