This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will prospectively assess the importance of environmental factors in relations to the development of immune responses and asthma phenotype in children in the inner city. This environment has several unique features that are likely to alter immune development by affecting the mother and the intrauterine environment, and also through continued effects on immune development during infancy. The URECA study will be a longitudinal prospective evaluation over a three year period, beginning at birth. The primary outcome to be evaluated is the relationship between the development of cytokine dysregulation in the first three years of life, to the acquisition of recurrent wheezing at the age of three years. Secondary objectives are to evaluate the effects of environmental factors on the development of cytokine dysregulaton, wheezing and asthma.
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