This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.PBTC-020 is a multi-center pediatric phase I trial of AZD2171 that will be performed in children and adolescents with recurrent or refractory tumors of the central nervous system, to determine the maximum tolerated dose (MTD) and safety profile of AZD2171 in this population. AZD2171 will be administered by mouth once daily for 28 consecutive days in two strata: a) Stratum I: those who are not receiving enzyme inducing anticonvulsant drugs (EIACD) and b) Stratum II: those who are receiving enzyme inducing anticonvulsant drugs (EIACD). Patients will be treated with escalating doses of AZD2171. Each course will last for 28 consecutive days and treatment may continue without breaks for up to 13 courses or one year. Dose escalations will be performed with each cohort in each stratum.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000037-47
Application #
7603586
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2007-09-16
Budget Start
2007-04-01
Budget End
2007-09-16
Support Year
47
Fiscal Year
2007
Total Cost
$305
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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