There is a need to determine in more detail the biological, psychological, and social factors involved in tobacco smoking behavior in persons who are aware of the harmful health consequences of continued tobacco use. The brain is the principal organ of behavior in the body. Hence, a great deal of interest is not focused on brain imaging of nicotine an tobacco smoking using a variety of imaging techniques. One brain mapping procedure is the quantitative electroencephalographic technique, where it is possible to quantify brain changes using colored topographic mapping. Such studies have shown that tobacco smoking produces an EEG pattern consistent with a behavioral wakeup effect. To date, no topographic EEG studies have been reported that compare the effects of pure nicotine via routes of administration such as nasal spray to that of tobacco smoking. In this research we will compare the effects of nicotine nasal spray to those of tobacco smoke using the quantitative electroencephalographic technique with colored topographic mapping. Subjects are recruited bvia advertisements in local newspapers, via community bulletin boards, and other public places. To participate, individuals must be healthy, drug-free male and female cigarette smokers. Following a screening procedure and signing of the consent form subjects will be scheduled for two testing sessions. During one session the subject will receive nicotine nasal spray (preceded by placebo nasal spray), and during the other session the subject will smoke a research nicotine-containing cigarette (preceded by a very low nicotine-containing placebo cigarette). Blood will be drawn from arm veins to measure nicotine concentrations in the blood during both sessions. A total of 60 mls (two tablespoons) of blood will be drawn during each of the two sessions. During smoking or administration of nasal spray, EEG readings will be recorded by computer using scalp electrodes (placed using local adhesive on the scalp). Each study sessions will last approximately two hours.

National Institute of Health (NIH)
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General Clinical Research Centers Program (M01)
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General Clinical Research Centers Committee (CLR)
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University of Michigan Ann Arbor
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Robarge, Jason D; Desta, Zereunesay; Nguyen, Anne T et al. (2017) Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer. Breast Cancer Res Treat 161:453-461
Crane, Natania A; Jenkins, Lisanne M; Bhaumik, Runa et al. (2017) Multidimensional prediction of treatment response to antidepressants with cognitive control and functional MRI. Brain 140:472-486
Hertz, Daniel L; Speth, Kelly A; Kidwell, Kelley M et al. (2017) Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients. Breast Cancer Res Treat 165:659-668
Hertz, D L; Kidwell, K M; Seewald, N J et al. (2017) Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer. Pharmacogenomics J 17:521-527
Kadakia, Kunal C; Kidwell, Kelley M; Seewald, Nicholas J et al. (2017) Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors. Breast Cancer Res Treat 164:411-419
Spengler, Erin K; Kleiner, David E; Fontana, Robert J (2017) Vemurafenib-induced granulomatous hepatitis. Hepatology 65:745-748
Heidemann, Lauren; Law, James; Fontana, Robert J (2017) A Text Searching Tool to Identify Patients with Idiosyncratic Drug-Induced Liver Injury. Dig Dis Sci 62:615-625
Law, Ian H; Alam, Osman; Bove, Edward L et al. (2016) Follow-Up of a Prospective Surgical Strategy to Prevent Intra-Atrial Reentrant Tachycardia After the Fontan Operation. Circ Arrhythm Electrophysiol 9:
Schrepf, Andrew; Harper, Daniel E; Harte, Steven E et al. (2016) Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study. Pain 157:2217-2225
As-Sanie, Sawsan; Kim, Jieun; Schmidt-Wilcke, Tobias et al. (2016) Functional Connectivity is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain. J Pain 17:1-13

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