This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our hypothesis is that eccentric resistance exercise will require less cardiopulmonary demands than concentric resistance exercise when performing the same work. We therefore plan to evaluate the O2 consumption/CO2 production during these two different types of resistance exercises in young (21-30 years) men and women and older subjects (>55 years of age; part II). These metabolic markers will also be affected by total skeletal musculature. Thus, in comparing measures in young versus older subjects, we will correct measures for lean body mass (both total and appendicular) as determined by DEXA scanning. In summary, understanding which type of resistance exercise that is least likely to cause greater cardiopulmonary effort will be important in developing rehabilitation exercises for older patients with chronic heart or lung disease complicated by muscle loss and weakness.
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